Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study

Antoine Racine; Franck Carbonnel; Simon S M Chan; Andrew R Hart; H Bas Bueno-de-Mesquita; Bas Oldenburg; Fiona D M van Schaik; Anne Tjønneland; Anja Olsen; Christina C Dahm; Timothy Key; Robert Luben; Kay-Tee Khaw; Elio Riboli; Olof Grip; Stefan Lindgren; Göran Hallmans; Pontus Karling; Françoise Clavel-Chapelon; Manuela M Bergman; Heiner Boeing; Rudolf Kaaks; Verena A Katzke; Domenico Palli; G Masala; Prevost Jantchou; Marie-Christine Boutron-Ruault

doi:10.1097/MIB.0000000000000638

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study

Antoine Racine, Franck Carbonnel, Simon S M Chan, Andrew R Hart, H Bas Bueno-de-Mesquita, Bas Oldenburg, Fiona D M van Schaik, Anne Tjønneland, Anja Olsen, Christina C Dahm, Timothy Key, Robert Luben, Kay-Tee Khaw, Elio Riboli, Olof Grip, Stefan Lindgren, Göran Hallmans, Pontus Karling, Françoise Clavel-Chapelon, Manuela M BergmanHeiner Boeing, Rudolf Kaaks, Verena A Katzke, Domenico Palli, G Masala, Prevost Jantchou, Marie-Christine Boutron-Ruault

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.

METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis.

RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a "high sugar and soft drinks" pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.

CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.

Original language	English
Pages (from-to)	345-354
Number of pages	10
Journal	Inflammatory bowel diseases
Volume	22
Issue number	2
DOIs	https://doi.org/10.1097/MIB.0000000000000638
Publication status	Published - Feb 2016

Keywords

Adult
Aged
Aged, 80 and over
Case-Control Studies
Colitis, Ulcerative
Crohn Disease
Diet
Europe
Female
Follow-Up Studies
Humans
Incidence
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Young Adult
Comparative Study
environmental factors
Randomized Controlled Trial
nutrition
dietary pattern
IBD

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Racine, A., Carbonnel, F., Chan, S. S. M., Hart, A. R., Bueno-de-Mesquita, H. B., Oldenburg, B., van Schaik, F. D. M., Tjønneland, A., Olsen, A., Dahm, C. C., Key, T., Luben, R., Khaw, K.-T., Riboli, E., Grip, O., Lindgren, S., Hallmans, G., Karling, P., Clavel-Chapelon, F., ... Boutron-Ruault, M.-C. (2016). Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study. Inflammatory bowel diseases, 22(2), 345-354. https://doi.org/10.1097/MIB.0000000000000638

@article{37635b02c0ab45049417930806d81db9,

title = "Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study",

abstract = "BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis.RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a {"}high sugar and soft drinks{"} pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.",

keywords = "Adult, Aged, Aged, 80 and over, Case-Control Studies, Colitis, Ulcerative, Crohn Disease, Diet, Europe, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Young Adult, Comparative Study, environmental factors, Randomized Controlled Trial, nutrition, dietary pattern, IBD",

author = "Antoine Racine and Franck Carbonnel and Chan, {Simon S M} and Hart, {Andrew R} and Bueno-de-Mesquita, {H Bas} and Bas Oldenburg and {van Schaik}, {Fiona D M} and Anne Tj{\o}nneland and Anja Olsen and Dahm, {Christina C} and Timothy Key and Robert Luben and Kay-Tee Khaw and Elio Riboli and Olof Grip and Stefan Lindgren and G{\"o}ran Hallmans and Pontus Karling and Fran{\c c}oise Clavel-Chapelon and Bergman, {Manuela M} and Heiner Boeing and Rudolf Kaaks and Katzke, {Verena A} and Domenico Palli and G Masala and Prevost Jantchou and Marie-Christine Boutron-Ruault",

year = "2016",

month = feb,

doi = "10.1097/MIB.0000000000000638",

language = "English",

volume = "22",

pages = "345--354",

journal = "Inflammatory bowel diseases",

issn = "1078-0998",

publisher = "John Wiley & Sons Inc.",

number = "2",

}

Racine, A, Carbonnel, F, Chan, SSM, Hart, AR, Bueno-de-Mesquita, HB, Oldenburg, B, van Schaik, FDM, Tjønneland, A, Olsen, A, Dahm, CC, Key, T, Luben, R, Khaw, K-T, Riboli, E, Grip, O, Lindgren, S, Hallmans, G, Karling, P, Clavel-Chapelon, F, Bergman, MM, Boeing, H, Kaaks, R, Katzke, VA, Palli, D, Masala, G, Jantchou, P & Boutron-Ruault, M-C 2016, 'Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study', Inflammatory bowel diseases, vol. 22, no. 2, pp. 345-354. https://doi.org/10.1097/MIB.0000000000000638

TY - JOUR

T1 - Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe

T2 - Results from the EPIC Study

AU - Racine, Antoine

AU - Carbonnel, Franck

AU - Chan, Simon S M

AU - Hart, Andrew R

AU - Bueno-de-Mesquita, H Bas

AU - Oldenburg, Bas

AU - van Schaik, Fiona D M

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Dahm, Christina C

AU - Key, Timothy

AU - Luben, Robert

AU - Khaw, Kay-Tee

AU - Riboli, Elio

AU - Grip, Olof

AU - Lindgren, Stefan

AU - Hallmans, Göran

AU - Karling, Pontus

AU - Clavel-Chapelon, Françoise

AU - Bergman, Manuela M

AU - Boeing, Heiner

AU - Kaaks, Rudolf

AU - Katzke, Verena A

AU - Palli, Domenico

AU - Masala, G

AU - Jantchou, Prevost

AU - Boutron-Ruault, Marie-Christine

PY - 2016/2

Y1 - 2016/2

N2 - BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis.RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a "high sugar and soft drinks" pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.

AB - BACKGROUND: Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.METHODS: Within the prospective EPIC (European Prospective Investigation into Cancer) study, we set up a nested matched case-control study among 366,351 participants with inflammatory bowel disease data, including 256 incident cases of UC and 117 of CD, and 4 matched controls per case. Dietary intake was recorded at baseline from validated food frequency questionnaires. Incidence rate ratios of developing UC and CD were calculated for quintiles of the Mediterranean diet score and a posteriori dietary patterns produced by factor analysis.RESULTS: No dietary pattern was associated with either UC or CD risks. However, when excluding cases occurring within the first 2 years after dietary assessment, there was a positive association between a "high sugar and soft drinks" pattern and UC risk (incidence rate ratios for the fifth versus first quintile, 1.68 [1.00-2.82]; Ptrend = 0.02). When considering the foods most associated with the pattern, high consumers of sugar and soft drinks were at higher UC risk only if they had low vegetables intakes.CONCLUSIONS: A diet imbalance with high consumption of sugar and soft drinks and low consumption of vegetables was associated with UC risk. Further studies are needed to investigate whether microbiota alterations or other mechanisms mediate this association.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Colitis, Ulcerative

KW - Crohn Disease

KW - Diet

KW - Europe

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Risk Factors

KW - Young Adult

KW - Comparative Study

KW - environmental factors

KW - Randomized Controlled Trial

KW - nutrition

KW - dietary pattern

KW - IBD

U2 - 10.1097/MIB.0000000000000638

DO - 10.1097/MIB.0000000000000638

M3 - Article

C2 - 26717318

SN - 1078-0998

VL - 22

SP - 345

EP - 354

JO - Inflammatory bowel diseases

JF - Inflammatory bowel diseases

IS - 2

ER -

Dietary Patterns and Risk of Inflammatory Bowel Disease in Europe: Results from the EPIC Study

Abstract

Keywords

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