TY - JOUR
T1 - Dietary folate intake and pancreatic cancer risk
T2 - Results from the European prospective investigation into cancer and nutrition
AU - Park, Jin Young
AU - Bueno-de-Mesquita, H. Bas
AU - Ferrari, Pietro
AU - Weiderpass, Elisabete
AU - de Batlle, Jordi
AU - Tjønneland, Anne
AU - Kyro, Cecilie
AU - Rebours, Vinciane
AU - Boutron-Ruault, Marie Christine
AU - Mancini, Francesca Romana
AU - Katzke, Verena
AU - Kühn, Tilman
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - La Vecchia, Carlo
AU - Kritikou, Maria
AU - Masala, Giovanna
AU - Pala, Valeria
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - Peeters, Petra H.
AU - Skeie, Guri
AU - Merino, Susana
AU - Duell, Eric J.
AU - Rodríguez-Barranco, Miguel
AU - Dorronsoro, Miren
AU - Chirlaque, Maria Dolores
AU - Ardanaz, Eva
AU - Gylling, Björn
AU - Schneede, Jörn
AU - Ericson, Ulrika
AU - Sternby, Hanna
AU - Khaw, Kay Tee
AU - Bradbury, Kathryn E.
AU - Huybrechts, Inge
AU - Aune, Dagfinn
AU - Vineis, Paolo
AU - Slimani, Nadia
N1 - Funding Information:
Key words: dietary folate intake, pancreatic cancer, EPIC study Grant sponsor: European Commission (DG-SANCO); Grant sponsor: International Agency for Research on Cancer; Grant sponsor: Danish Cancer Society (Denmark); Grant sponsor: Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale, Institut National de la Santé et de la Recherche Médicale (INSERM) (France); Grant sponsor: German Cancer Aid, Federal Ministry of Education and Research (BMBF), Deutsche Krebshilfe, Deutsches Krebsforschungszentrum and Federal Ministry of Education and Research (Germany); Grant sponsor: The Hellenic Health Foundation (Greece); Grant sponsor: Associazione Italiana per la Ricerca sul Cancro– AIRC–Italy and National Research Council (Italy); Grant sponsor: Dutch Ministry of Public Health, Welfare and Sports (VWS), Netherlands Cancer Registry (NKR), LK Research Funds, Dutch Prevention Funds, Dutch ZON (Zorg Onderzoek Nederland), World Cancer Research Fund (WCRF), Statistics Netherlands (The Netherlands); Grant sponsor: Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Grant sponsor: Health Research Fund (FIS): PI13/00061 to Granada, PI13/01162 to EPIC-Murcia, Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Grant sponsor: Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Grant sponsor: Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom) DOI: 10.1002/ijc.31830 History: Received 2 Mar 2018; Accepted 17 Jul 2018; Online 4 Sep 2018 Correspondence to: Jin Young Park, Prevention and Implementation Group, International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France, Tel.: +33-4-72-73-81-63, Fax: +33-4-72-73-86-63, E-mail: [email protected]
Funding Information:
Kathryn E. Bradbury declares that she a potential financial conflict of interest with her spouse having been a brewer at Loose Cannon Brewery Company Ltd., while the work was being done. All other authors declare that they have no conflict of interest. The work was undertaken during the tenure of a Postdoctoral Fellowship from the International Agency for Research on Cancer, partially supported by the European Commission FP7 Marie Curie Actions – People – Co-funding of regional, national and international programmes.
Publisher Copyright:
© 2018 UICC
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; p trend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, p trend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p interaction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
AB - Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, but not consistently with PC risk. We aimed to investigate the association between dietary folate intake and PC risk, using the standardised folate database across 10 European countries. A total of 477,206 participants were followed up for 11 years, during which 865 incident primary PC cases were recorded. Folate intake was energy-adjusted using the residual method. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models. In multivariable analyses stratified by age, sex, study centre and adjusted for energy intake, smoking status, BMI, educational level, diabetes status, supplement use and dietary fibre intake, we found no significant association between folate intake and PC risk: the HR of PC risk for those in the highest quartile of folate intake (≥353 μg/day) compared to the lowest (<241 μg/day) was 0.81 (95% CI: 0.51, 1.31; p trend = 0.38). In current smokers, a positive trend was observed in PC risk across folate quartiles [HR = 4.42 (95% CI: 1.05, 18.62) for ≥353 μg/day vs. <241 μg/day, p trend = 0.01]. Nonetheless, there was no significant interaction between smoking and dietary folate intake (p interaction = 0.99). We found no association between dietary folate intake and PC risk in this large European study.
KW - dietary folate intake
KW - EPIC study
KW - pancreatic cancer
KW - Prospective Studies
KW - Follow-Up Studies
KW - Humans
KW - Middle Aged
KW - Self Report
KW - Proportional Hazards Models
KW - Male
KW - Smoking/adverse effects
KW - Pancreatic Neoplasms/epidemiology
KW - Europe/epidemiology
KW - Folic Acid/administration & dosage
KW - Adult
KW - Female
KW - Nutritional Status
UR - http://www.scopus.com/inward/record.url?scp=85058931652&partnerID=8YFLogxK
U2 - 10.1002/ijc.31830
DO - 10.1002/ijc.31830
M3 - Article
C2 - 30178496
AN - SCOPUS:85058931652
SN - 0020-7136
VL - 144
SP - 1511
EP - 1521
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -