Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Raul Zamora-Ros; Dinesh K. Barupal; Joseph A. Rothwell; Mazda Jenab; Veronika Fedirko; Isabelle Romieu; Krasimira Aleksandrova; Kim Overvad; Cecilie Kyrø; Anne Tjønneland; Aurélie Affret; Mathilde His; Marie Christine Boutron-Ruault; Verena Katzke; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Androniki Naska; Maria Kritikou; Calogero Saieva; Claudia Agnoli; Maria Santucci de Magistris; Rosario Tumino; Francesca Fasanelli; Elisabete Weiderpass; Guri Skeie; Susana Merino; Paula Jakszyn; Maria José Sánchez; Miren Dorronsoro; Carmen Navarro; Eva Ardanaz; Emily Sonestedt; Ulrika Ericson; Lena Maria Nilsson; Stina Bodén; H. Bas Bueno-de-Mesquita; Petra H. Peeters; Aurora Perez-Cornago; Nicholas J. Wareham; Kay Thee Khaw; Heinz Freisling; Amanda J. Cross; Elio Riboli; Augustin Scalbert

doi:10.1002/ijc.30582

Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

Raul Zamora-Ros, Dinesh K. Barupal, Joseph A. Rothwell, Mazda Jenab, Veronika Fedirko, Isabelle Romieu, Krasimira Aleksandrova, Kim Overvad, Cecilie Kyrø, Anne Tjønneland, Aurélie Affret, Mathilde His, Marie Christine Boutron-Ruault, Verena Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Androniki Naska, Maria Kritikou, Calogero SaievaClaudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Francesca Fasanelli, Elisabete Weiderpass, Guri Skeie, Susana Merino, Paula Jakszyn, Maria José Sánchez, Miren Dorronsoro, Carmen Navarro, Eva Ardanaz, Emily Sonestedt, Ulrika Ericson, Lena Maria Nilsson, Stina Bodén, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Aurora Perez-Cornago, Nicholas J. Wareham, Kay Thee Khaw, Heinz Freisling, Amanda J. Cross, Elio Riboli, Augustin Scalbert^*

^*Corresponding author for this work

Cancer

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

Original language	English
Pages (from-to)	1836-1844
Number of pages	9
Journal	International Journal of Cancer
Volume	140
Issue number	8
DOIs	https://doi.org/10.1002/ijc.30582
Publication status	Published - 15 Apr 2017

Keywords

Colorectal cancer
Diet
EPIC
Flavonoids
Prospective cohort

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Zamora-Ros, R., Barupal, D. K., Rothwell, J. A., Jenab, M., Fedirko, V., Romieu, I., Aleksandrova, K., Overvad, K., Kyrø, C., Tjønneland, A., Affret, A., His, M., Boutron-Ruault, M. C., Katzke, V., Kühn, T., Boeing, H., Trichopoulou, A., Naska, A., Kritikou, M., ... Scalbert, A. (2017). Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort. International Journal of Cancer, 140(8), 1836-1844. https://doi.org/10.1002/ijc.30582

@article{c1f106f2817e4d25a14dbe9ff6b8c2dc,

title = "Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort",

abstract = "Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.",

keywords = "Colorectal cancer, Diet, EPIC, Flavonoids, Prospective cohort",

author = "Raul Zamora-Ros and Barupal, {Dinesh K.} and Rothwell, {Joseph A.} and Mazda Jenab and Veronika Fedirko and Isabelle Romieu and Krasimira Aleksandrova and Kim Overvad and Cecilie Kyr{\o} and Anne Tj{\o}nneland and Aur{\'e}lie Affret and Mathilde His and Boutron-Ruault, {Marie Christine} and Verena Katzke and Tilman K{\"u}hn and Heiner Boeing and Antonia Trichopoulou and Androniki Naska and Maria Kritikou and Calogero Saieva and Claudia Agnoli and {Santucci de Magistris}, Maria and Rosario Tumino and Francesca Fasanelli and Elisabete Weiderpass and Guri Skeie and Susana Merino and Paula Jakszyn and S{\'a}nchez, {Maria Jos{\'e}} and Miren Dorronsoro and Carmen Navarro and Eva Ardanaz and Emily Sonestedt and Ulrika Ericson and {Maria Nilsson}, Lena and Stina Bod{\'e}n and {Bas Bueno-de-Mesquita}, H. and Peeters, {Petra H.} and Aurora Perez-Cornago and Wareham, {Nicholas J.} and Khaw, {Kay Thee} and Heinz Freisling and Cross, {Amanda J.} and Elio Riboli and Augustin Scalbert",

year = "2017",

month = apr,

day = "15",

doi = "10.1002/ijc.30582",

language = "English",

volume = "140",

pages = "1836--1844",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley & Sons Inc.",

number = "8",

}

Zamora-Ros, R, Barupal, DK, Rothwell, JA, Jenab, M, Fedirko, V, Romieu, I, Aleksandrova, K, Overvad, K, Kyrø, C, Tjønneland, A, Affret, A, His, M, Boutron-Ruault, MC, Katzke, V, Kühn, T, Boeing, H, Trichopoulou, A, Naska, A, Kritikou, M, Saieva, C, Agnoli, C, Santucci de Magistris, M, Tumino, R, Fasanelli, F, Weiderpass, E, Skeie, G, Merino, S, Jakszyn, P, Sánchez, MJ, Dorronsoro, M, Navarro, C, Ardanaz, E, Sonestedt, E, Ericson, U, Maria Nilsson, L, Bodén, S, Bas Bueno-de-Mesquita, H, Peeters, PH, Perez-Cornago, A, Wareham, NJ, Khaw, KT, Freisling, H, Cross, AJ, Riboli, E & Scalbert, A 2017, 'Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort', International Journal of Cancer, vol. 140, no. 8, pp. 1836-1844. https://doi.org/10.1002/ijc.30582

TY - JOUR

T1 - Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

AU - Zamora-Ros, Raul

AU - Barupal, Dinesh K.

AU - Rothwell, Joseph A.

AU - Jenab, Mazda

AU - Fedirko, Veronika

AU - Romieu, Isabelle

AU - Aleksandrova, Krasimira

AU - Overvad, Kim

AU - Kyrø, Cecilie

AU - Tjønneland, Anne

AU - Affret, Aurélie

AU - His, Mathilde

AU - Boutron-Ruault, Marie Christine

AU - Katzke, Verena

AU - Kühn, Tilman

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Naska, Androniki

AU - Kritikou, Maria

AU - Saieva, Calogero

AU - Agnoli, Claudia

AU - Santucci de Magistris, Maria

AU - Tumino, Rosario

AU - Fasanelli, Francesca

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Merino, Susana

AU - Jakszyn, Paula

AU - Sánchez, Maria José

AU - Dorronsoro, Miren

AU - Navarro, Carmen

AU - Ardanaz, Eva

AU - Sonestedt, Emily

AU - Ericson, Ulrika

AU - Maria Nilsson, Lena

AU - Bodén, Stina

AU - Bas Bueno-de-Mesquita, H.

AU - Peeters, Petra H.

AU - Perez-Cornago, Aurora

AU - Wareham, Nicholas J.

AU - Khaw, Kay Thee

AU - Freisling, Heinz

AU - Cross, Amanda J.

AU - Riboli, Elio

AU - Scalbert, Augustin

PY - 2017/4/15

Y1 - 2017/4/15

N2 - Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

AB - Flavonoids have been shown to inhibit colon cancer cell proliferation in vitro and protect against colorectal carcinogenesis in animal models. However, epidemiological evidence on the potential role of flavonoid intake in colorectal cancer (CRC) development remains sparse and inconsistent. We evaluated the association between dietary intakes of total flavonoids and their subclasses and risk of development of CRC, within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. A cohort of 477,312 adult men and women were recruited in 10 European countries. At baseline, dietary intakes of total flavonoids and individual subclasses were estimated using centre-specific validated dietary questionnaires and composition data from the Phenol-Explorer database. During an average of 11 years of follow-up, 4,517 new cases of primary CRC were identified, of which 2,869 were colon (proximal=1,298 and distal=1,266) and 1,648 rectal tumours. No association was found between total flavonoid intake and the risk of overall CRC (HR for comparison of extreme quintiles 1.05, 95% CI 0.93-1.18; p-trend=0.58) or any CRC subtype. No association was also observed with any intake of individual flavonoid subclasses. Similar results were observed for flavonoid intake expressed as glycosides or aglycone equivalents. Intake of total flavonoids and flavonoid subclasses, as estimated from dietary questionnaires, did not show any association with risk of CRC development.

KW - Colorectal cancer

KW - Diet

KW - EPIC

KW - Flavonoids

KW - Prospective cohort

UR - http://www.scopus.com/inward/record.url?scp=85010629654&partnerID=8YFLogxK

U2 - 10.1002/ijc.30582

DO - 10.1002/ijc.30582

M3 - Article

C2 - 28006847

AN - SCOPUS:85010629654

SN - 0020-7136

VL - 140

SP - 1836

EP - 1844

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 8

ER -

Dietary flavonoid intake and colorectal cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort

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Keywords

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