Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases

W F Julius Scheurleer; Weibel W Braunius; Bernard M Tijink; Luuk M Janssen; Frank A Pameijer; Gerben E Breimer; Ernst J Smid; Remco de Bree; Lot A Devriese; Johannes A Rijken

doi:10.1155/2023/4788617

Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases

W F Julius Scheurleer^*, Weibel W Braunius, Bernard M Tijink, Luuk M Janssen, Frank A Pameijer, Gerben E Breimer, Ernst J Smid, Remco de Bree, Lot A Devriese, Johannes A Rijken

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

14 Downloads (Pure)

Abstract

BACKGROUND: Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition.

METHODS: Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted.

RESULTS: Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease.

CONCLUSION: Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)-radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.

Original language	English
Article number	4788617
Journal	Case reports in otolaryngology
Volume	2023
DOIs	https://doi.org/10.1155/2023/4788617
Publication status	Published - Nov 2023

Access to Document

10.1155/2023/4788617Licence: CC BY

4788617Final published version, 1.93 MBLicence: CC BY

Cite this

@article{0b1f179bcd474f24934b369c69b3be2b,

title = "Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases",

abstract = "BACKGROUND: Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition.METHODS: Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted.RESULTS: Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease.CONCLUSION: Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)-radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.",

author = "Scheurleer, {W F Julius} and Braunius, {Weibel W} and Tijink, {Bernard M} and Janssen, {Luuk M} and Pameijer, {Frank A} and Breimer, {Gerben E} and Smid, {Ernst J} and {de Bree}, Remco and Devriese, {Lot A} and Rijken, {Johannes A}",

note = "Copyright {\textcopyright} 2023 W. F. Julius Scheurleer et al.",

year = "2023",

month = nov,

doi = "10.1155/2023/4788617",

language = "English",

volume = "2023",

}

TY - JOUR

T1 - Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma

T2 - A Report of Three Cases

AU - Scheurleer, W F Julius

AU - Braunius, Weibel W

AU - Tijink, Bernard M

AU - Janssen, Luuk M

AU - Pameijer, Frank A

AU - Breimer, Gerben E

AU - Smid, Ernst J

AU - de Bree, Remco

AU - Devriese, Lot A

AU - Rijken, Johannes A

PY - 2023/11

Y1 - 2023/11

N2 - BACKGROUND: Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition.METHODS: Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted.RESULTS: Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease.CONCLUSION: Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)-radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.

AB - BACKGROUND: Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition.METHODS: Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted.RESULTS: Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease.CONCLUSION: Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)-radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.

U2 - 10.1155/2023/4788617

DO - 10.1155/2023/4788617

M3 - Article

C2 - 38028233

SN - 2090-6765

VL - 2023

JO - Case reports in otolaryngology

JF - Case reports in otolaryngology

M1 - 4788617

ER -

Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases

Abstract

Access to Document

Fingerprint

Cite this