TY - JOUR
T1 - Diagnostic agreement of quantitative flow ratio with fractional flow reserve in a Latin-American population
AU - Echavarría-Pinto, Mauro
AU - Van de Hoef, Tim P
AU - Pacheco-Beltran, Nancy
AU - Reyes-Carrera, Jesus Eduardo
AU - Rangel-Alvarado, Eduardo
AU - Ledezma-Ledezma, Elizabeth
AU - Aguilar-Castillo, Laura Alicia
AU - Tovar-Becerra, Andrea Itzel
AU - Arellano, Juan Ernesto Muñoz
AU - Ramírez, María Neftalí Maqueda
AU - Muruaga, Miriam
AU - Ibarra-Rangel, Ana Maria
AU - Montes-Collantes, Carlos Alberto
AU - Castrejon-Mora, Jorge Luis
AU - Chong-Benitez, Irma Hualtal
AU - Vargas-Torrrescano, Luis Homero
AU - García-García, Hector M
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature B.V.
PY - 2022/7
Y1 - 2022/7
N2 - Quantitative flow ratio (QFR) is a recently proposed angiographic index that allows to assess the pressure loss in coronary arteries in a similar fashion as the fractional flow reserve (FFR). The purpose of this study was to evaluate the diagnostic performance of QFR as compared to FFR, in a Latin-American population of patients with suspected ischaemic heart disease. QFR was retrospectively derived from coronary angiograms. The association, diagnostic performance, and continuous agreement of fixed-flow QFR (fQFR) and contrast-flow QFR (cQFR) with FFR was assessed by continuous and dichotomous methods. 90 vessels form 66 patients were finally included. The study comprised coronary stenoses of intermediate severity, both angiographically (diameter stenosis: 46.6 ± 12.8%) and physiologically [median FFR = 0.83 (quartile 1-3, 0.76-0.89)]. The correlation of FFR with both fQFR [ρ = 0.841, (95% CI 0.767 to 0.893), p < 0.001] and cQFR [ρ = 0.833, (95% CI 0.755 to 0.887), p < 0.001] was strong. The diagnostic performance of cQFR was good [area under the ROC curve of 0.92 (95% CI 0.86 to 0.97, p < 0.001)], with 0.80 as the optimal cQFR cut-off against FFR ≤ 0.80. This 0.80 cQFR cut-off classified correctly 83.3% of total stenoses, with a sensitivity of 85.2% and specificity of 80.6%. QFR was strongly associated with FFR and exhibited a high diagnostic performance in this Latin-American population.
AB - Quantitative flow ratio (QFR) is a recently proposed angiographic index that allows to assess the pressure loss in coronary arteries in a similar fashion as the fractional flow reserve (FFR). The purpose of this study was to evaluate the diagnostic performance of QFR as compared to FFR, in a Latin-American population of patients with suspected ischaemic heart disease. QFR was retrospectively derived from coronary angiograms. The association, diagnostic performance, and continuous agreement of fixed-flow QFR (fQFR) and contrast-flow QFR (cQFR) with FFR was assessed by continuous and dichotomous methods. 90 vessels form 66 patients were finally included. The study comprised coronary stenoses of intermediate severity, both angiographically (diameter stenosis: 46.6 ± 12.8%) and physiologically [median FFR = 0.83 (quartile 1-3, 0.76-0.89)]. The correlation of FFR with both fQFR [ρ = 0.841, (95% CI 0.767 to 0.893), p < 0.001] and cQFR [ρ = 0.833, (95% CI 0.755 to 0.887), p < 0.001] was strong. The diagnostic performance of cQFR was good [area under the ROC curve of 0.92 (95% CI 0.86 to 0.97, p < 0.001)], with 0.80 as the optimal cQFR cut-off against FFR ≤ 0.80. This 0.80 cQFR cut-off classified correctly 83.3% of total stenoses, with a sensitivity of 85.2% and specificity of 80.6%. QFR was strongly associated with FFR and exhibited a high diagnostic performance in this Latin-American population.
KW - Fractional flow reserve
KW - Ischaemic heart disease
KW - Percutaneous coronary intervention
KW - Quantitative flow ratio
UR - http://www.scopus.com/inward/record.url?scp=85124302040&partnerID=8YFLogxK
U2 - 10.1007/s10554-022-02547-6
DO - 10.1007/s10554-022-02547-6
M3 - Article
C2 - 35122581
SN - 1569-5794
VL - 38
SP - 1423
EP - 1430
JO - The International Journal of Cardiovascular Imaging
JF - The International Journal of Cardiovascular Imaging
IS - 7
ER -