Diagnostic accuracy of [
            99mTc]Tc-tilmanocept compared to [
            99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer

Rutger Mahieu; Inne J den Toom; Rob van Rooij; Robert J J van Es; Monique G G Hobbelink; Gerard C Krijger; Bernard M Tijink; Bart de Keizer; Remco de Bree

doi:10.1111/coa.13798

Diagnostic accuracy of [ ^99mTc]Tc-tilmanocept compared to [ ^99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer

Rutger Mahieu
, Inne J den Toom
, Rob van Rooij
, Robert J J van Es
, Monique G G Hobbelink
, Gerard C Krijger
, Bernard M Tijink
, Bart de Keizer
, Remco de Bree

Research output: Contribution to journal › Letter › Academic › peer-review

Abstract

This study compares sentinel lymph node identification using [99m Tc]Tc-tilmanocept to [99m Tc]Tc-nanocolloid in early-stage oral cancer patients In those who underwent lymphoscintigraphy using both radiotracers, presence of nodal metastasis was correctly identified by either radiotracer Sentinel lymph node biopsy using [99mTc]Tc-tilmanocept reached a sensitivity of 83.3% and negative predictive value of 93.3% Accuracy of sentinel lymph node biopsy using [99mTc]Tc-tilmanocept is comparable to using [99mTc]Tc-nanocolloid Tilmanocept may be an alternative for nanocolloid in sentinel lymph node biopsy.

Original language	English
Pages (from-to)	1383-1388
Number of pages	6
Journal	Clinical Otolaryngology
Volume	46
Issue number	6
Early online date	6 May 2021
DOIs	https://doi.org/10.1111/coa.13798
Publication status	Published - Nov 2021

Keywords

Lymph Node
Lymphoscintigraphy
metastasis
oral cancer
sentinel lymph node biopsy
[ Tc]Tc-tilmanocept

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10.1111/coa.13798

Clinical Otolaryngology - 2021 - Mahieu - Diagnostic accuracy of 99mTc Tc‐tilmanocept compared to 99mTc Tc‐nanocolloidFinal published version, 530 KBLicence: Taverne

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Mahieu, R., den Toom, I. J., van Rooij, R., van Es, R. J. J., Hobbelink, M. G. G., Krijger, G. C., Tijink, B. M., de Keizer, B., & de Bree, R. (2021). Diagnostic accuracy of [ ^99mTc]Tc-tilmanocept compared to [ ^99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer. Clinical Otolaryngology, 46(6), 1383-1388. https://doi.org/10.1111/coa.13798

@article{eeb6d79a00304dc2840fd275a8824143,

title = "Diagnostic accuracy of [ 99mTc]Tc-tilmanocept compared to [ 99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer",

abstract = "This study compares sentinel lymph node identification using [99m Tc]Tc-tilmanocept to [99m Tc]Tc-nanocolloid in early-stage oral cancer patients In those who underwent lymphoscintigraphy using both radiotracers, presence of nodal metastasis was correctly identified by either radiotracer Sentinel lymph node biopsy using [99mTc]Tc-tilmanocept reached a sensitivity of 83.3\% and negative predictive value of 93.3\% Accuracy of sentinel lymph node biopsy using [99mTc]Tc-tilmanocept is comparable to using [99mTc]Tc-nanocolloid Tilmanocept may be an alternative for nanocolloid in sentinel lymph node biopsy.",

keywords = "Lymph Node, Lymphoscintigraphy, metastasis, oral cancer, sentinel lymph node biopsy, [ Tc]Tc-tilmanocept",

author = "Rutger Mahieu and \{den Toom\}, \{Inne J\} and \{van Rooij\}, Rob and \{van Es\}, \{Robert J J\} and Hobbelink, \{Monique G G\} and Krijger, \{Gerard C\} and Tijink, \{Bernard M\} and \{de Keizer\}, Bart and \{de Bree\}, Remco",

note = "Funding Information: For the prequel prospective within‐patient evaluation study, financial support was obtained from SpePharm AG{\textemdash}part of the Norgine Group of companies, Amsterdam, The Netherlands. ",

year = "2021",

month = nov,

doi = "10.1111/coa.13798",

language = "English",

volume = "46",

pages = "1383--1388",

journal = "Clinical Otolaryngology",

issn = "1749-4478",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "6",

}

Mahieu, R, den Toom, IJ, van Rooij, R, van Es, RJJ, Hobbelink, MGG, Krijger, GC, Tijink, BM, de Keizer, B & de Bree, R 2021, 'Diagnostic accuracy of [ ^99mTc]Tc-tilmanocept compared to [ ^99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer', Clinical Otolaryngology, vol. 46, no. 6, pp. 1383-1388. https://doi.org/10.1111/coa.13798

Diagnostic accuracy of [ ^99mTc]Tc-tilmanocept compared to [ ^99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer. / Mahieu, Rutger; den Toom, Inne J; van Rooij, Rob et al.
In: Clinical Otolaryngology, Vol. 46, No. 6, 11.2021, p. 1383-1388.

Research output: Contribution to journal › Letter › Academic › peer-review

TY - JOUR

T1 - Diagnostic accuracy of [ 99mTc]Tc-tilmanocept compared to [ 99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer

AU - Mahieu, Rutger

AU - den Toom, Inne J

AU - van Rooij, Rob

AU - van Es, Robert J J

AU - Hobbelink, Monique G G

AU - Krijger, Gerard C

AU - Tijink, Bernard M

AU - de Keizer, Bart

AU - de Bree, Remco

N1 - Funding Information: For the prequel prospective within‐patient evaluation study, financial support was obtained from SpePharm AG—part of the Norgine Group of companies, Amsterdam, The Netherlands.

PY - 2021/11

Y1 - 2021/11

N2 - This study compares sentinel lymph node identification using [99m Tc]Tc-tilmanocept to [99m Tc]Tc-nanocolloid in early-stage oral cancer patients In those who underwent lymphoscintigraphy using both radiotracers, presence of nodal metastasis was correctly identified by either radiotracer Sentinel lymph node biopsy using [99mTc]Tc-tilmanocept reached a sensitivity of 83.3% and negative predictive value of 93.3% Accuracy of sentinel lymph node biopsy using [99mTc]Tc-tilmanocept is comparable to using [99mTc]Tc-nanocolloid Tilmanocept may be an alternative for nanocolloid in sentinel lymph node biopsy.

AB - This study compares sentinel lymph node identification using [99m Tc]Tc-tilmanocept to [99m Tc]Tc-nanocolloid in early-stage oral cancer patients In those who underwent lymphoscintigraphy using both radiotracers, presence of nodal metastasis was correctly identified by either radiotracer Sentinel lymph node biopsy using [99mTc]Tc-tilmanocept reached a sensitivity of 83.3% and negative predictive value of 93.3% Accuracy of sentinel lymph node biopsy using [99mTc]Tc-tilmanocept is comparable to using [99mTc]Tc-nanocolloid Tilmanocept may be an alternative for nanocolloid in sentinel lymph node biopsy.

KW - Lymph Node

KW - Lymphoscintigraphy

KW - metastasis

KW - oral cancer

KW - sentinel lymph node biopsy

KW - [ Tc]Tc-tilmanocept

UR - https://www.scopus.com/pages/publications/85107147474

U2 - 10.1111/coa.13798

DO - 10.1111/coa.13798

M3 - Letter

C2 - 33960126

SN - 1749-4478

VL - 46

SP - 1383

EP - 1388

JO - Clinical Otolaryngology

JF - Clinical Otolaryngology

IS - 6

ER -

Diagnostic accuracy of [ ^99mTc]Tc-tilmanocept compared to [ ^99mTc]Tc-nanocolloid for sentinel lymph node identification in early-stage oral cancer

Abstract

Keywords

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