Diagnostic accuracy of needle-localized open breast biopsy for impalpable breast disease

H.M. Verkooijen, P.H.M. Peeters, R.M. Pijnappel, V.C.M. Koot, M.E.I. Schipper, I.H.M. Borel Rinkes

Research output: Contribution to journalArticleAcademicpeer-review


BACKGROUND: Needle-localized open breast biopsy (NLBB) is considered the gold standard procedure for the diagnosis of impalpable breast disease. In an observational follow-up study the sensitivity and negative predictive value of this procedure was determined in a clinical population with long-term follow-up.

METHODS: Some 199 consecutive patients with a benign histological diagnosis on NLBB were followed for the occurrence of breast cancer, using information from the Dutch National Morbid-Anatomical Record Department. Based on a review of mammograms and histological slides, an expert panel decided whether the carcinomas detected during follow-up were newly developed, or were present already at the time of the NLBB.

RESULTS: After a median follow-up of 60.5 months, seven carcinomas were detected. At panel review, six appeared to have been missed by NLBB. The sensitivity of NLBB was 99 per cent after 2 years of follow-up, but dropped to 96 per cent after 5 years. Similarly, the negative predictive value dropped from 99 per cent after 2 years to 94 per cent after 5 years of follow-up.

CONCLUSION: NLBB is an accurate diagnostic procedure for the evaluation of impalpable breast disease. However, with longer follow-up the accuracy becomes lower than generally reported.

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalBritish Journal of Surgery
Issue number3
Publication statusPublished - 2000


  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy, Needle
  • Breast
  • Breast Diseases
  • Female
  • Follow-Up Studies
  • Humans
  • Middle Aged
  • Palpation
  • Sensitivity and Specificity
  • Journal Article
  • Research Support, Non-U.S. Gov't


Dive into the research topics of 'Diagnostic accuracy of needle-localized open breast biopsy for impalpable breast disease'. Together they form a unique fingerprint.

Cite this