TY - JOUR
T1 - Diagnosis of Cytomegalovirus Anterior Uveitis in Two European Referral Centers
AU - Relvas, Lia Judice M.
AU - Antoun, Joelle
AU - de Groot-Mijnes, Jolanda D.F.
AU - Motulsky, Elie
AU - Ten Dam-Van Loon, Ninette H.
AU - Makhoul, Dorine
AU - Willermain, François
AU - Caspers, Laure
N1 - Publisher Copyright:
©, Published by Taylor & Francis. © 2018 Lia Judice M. Relvas, Joelle Antoun, Jolanda D.F. de Groot-Mijnes, Elie Motulsky, Ninette H. Ten Dam-Van Loon, Dorine Makhoul, François Willermain, and Laure Caspers.
PY - 2018/1/2
Y1 - 2018/1/2
N2 - Purpose: To evaluate diagnostic methods and clinical signs of CMV anterior uveitis (AU), a rarely described entity in Europe. Methods: We included patients with clinical characteristics of CMV AU and positive PCR and/or Goldmann-Witmer coefficient (GWc) for CMV. Results: We report 21 patients with unilateral uveitis (100%) and signs of Posner-Schlossman syndrome (PSS) (n = 20, 95.2%), Fuchs uveitis syndrome (FUS) (n = 1, 4.7%), and endotheliitis (n = 4, 19,04%). PCR was positive in 15/21 (71.4%) and GWc in 8/9 patients (88.9%) in aqueous for CMV. GWc was the only positive test in 6/9 patients (66,6%). When PCR alone was performed (without GWc) in the first tap, repeated aqueous taps were needed, twice in five cases and thrice in one case. Conclusion: Combining PCR and GWc were very helpful to confirm the clinical diagnosis of CMV AU. In case of very high clinical suspicion and negative results, repeated tap seems to be recommended.
AB - Purpose: To evaluate diagnostic methods and clinical signs of CMV anterior uveitis (AU), a rarely described entity in Europe. Methods: We included patients with clinical characteristics of CMV AU and positive PCR and/or Goldmann-Witmer coefficient (GWc) for CMV. Results: We report 21 patients with unilateral uveitis (100%) and signs of Posner-Schlossman syndrome (PSS) (n = 20, 95.2%), Fuchs uveitis syndrome (FUS) (n = 1, 4.7%), and endotheliitis (n = 4, 19,04%). PCR was positive in 15/21 (71.4%) and GWc in 8/9 patients (88.9%) in aqueous for CMV. GWc was the only positive test in 6/9 patients (66,6%). When PCR alone was performed (without GWc) in the first tap, repeated aqueous taps were needed, twice in five cases and thrice in one case. Conclusion: Combining PCR and GWc were very helpful to confirm the clinical diagnosis of CMV AU. In case of very high clinical suspicion and negative results, repeated tap seems to be recommended.
KW - Adult
KW - Anterior Eye Segment
KW - Antibodies, Viral
KW - Antiviral Agents
KW - Cytomegalovirus
KW - Cytomegalovirus Infections
KW - DNA, Viral
KW - Europe
KW - Eye Infections, Viral
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Real-Time Polymerase Chain Reaction
KW - Referral and Consultation
KW - Retrospective Studies
KW - Uveitis, Anterior
UR - http://www.scopus.com/inward/record.url?scp=85041335892&partnerID=8YFLogxK
U2 - 10.1080/09273948.2017.1411952
DO - 10.1080/09273948.2017.1411952
M3 - Article
C2 - 29377783
SN - 0927-3948
VL - 26
SP - 116
EP - 121
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 1
ER -