TY - JOUR
T1 - Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose
AU - Weijtens, Olga
AU - Schoemaker, Rik C.
AU - Lentjes, Eef G.W.M.
AU - Romijn, Fred P.H.T.M.
AU - Cohen, Adam F.
AU - Van Meurs, Jan C.
PY - 2000/10/24
Y1 - 2000/10/24
N2 - Purpose: To determine dexamethasone concentrations in the subretinal fluid of patients after a peribulbar injection, a subconjunctival injection, or an oral dose of dexamethasone and to compare the results with those of previous similar studies of dexamethasone concentrations in the vitreous. Design: Prospective, nonrandomized, comparative trial. Participants: One hundred forty-eight patients with a rhegmatogenous retinal detachment. Methods: Fifty patients received a peribulbar injection of 5 mg dexamethasone disodium phosphate, 49 received a subconjunctival injection of 2.5 mg dexamethasone disodium phosphate, and 49 received an oral dose of 7.5 mg dexamethasone at various time intervals before surgery. At the time of surgery, a subretinal fluid sample was taken from each patient. Main Outcome Measures: The dexamethasone concentration in the subretinal fluid measured by radioimmunoassay. Results: The estimated maximum dexamethasone concentrations in the subretinal fluid after the peribulbar injection, the subconjunctival injection, and the oral dose were, respectively, 82.2 ng/ml (standard error, 17.6), 359 ng/ml (standard error, 80.2), and 12.3 ng/ml (standard error, 1.61). Corrected for dose, the maximum dexamethasone concentrations after subconjunctival injection and peribulbar injection were, respectively, 120 (95% confidence interval, 54/180) and 13 (95% confidence interval, 6.8/20) times greater than after oral administration. Conclusions: A subconjunctival injection of dexamethasone disodium phosphate is more effective in delivering dexamethasone into the subretinal fluid of patients with a rhegmatogenous retinal detachment compared with peribulbar injection or oral administration. The subretinal dexamethasone concentrations were higher than concentrations measured in the vitreous in previous studies with a similar setup after all three delivery methods. (C) 2000 American Academy of Ophthalmology.
AB - Purpose: To determine dexamethasone concentrations in the subretinal fluid of patients after a peribulbar injection, a subconjunctival injection, or an oral dose of dexamethasone and to compare the results with those of previous similar studies of dexamethasone concentrations in the vitreous. Design: Prospective, nonrandomized, comparative trial. Participants: One hundred forty-eight patients with a rhegmatogenous retinal detachment. Methods: Fifty patients received a peribulbar injection of 5 mg dexamethasone disodium phosphate, 49 received a subconjunctival injection of 2.5 mg dexamethasone disodium phosphate, and 49 received an oral dose of 7.5 mg dexamethasone at various time intervals before surgery. At the time of surgery, a subretinal fluid sample was taken from each patient. Main Outcome Measures: The dexamethasone concentration in the subretinal fluid measured by radioimmunoassay. Results: The estimated maximum dexamethasone concentrations in the subretinal fluid after the peribulbar injection, the subconjunctival injection, and the oral dose were, respectively, 82.2 ng/ml (standard error, 17.6), 359 ng/ml (standard error, 80.2), and 12.3 ng/ml (standard error, 1.61). Corrected for dose, the maximum dexamethasone concentrations after subconjunctival injection and peribulbar injection were, respectively, 120 (95% confidence interval, 54/180) and 13 (95% confidence interval, 6.8/20) times greater than after oral administration. Conclusions: A subconjunctival injection of dexamethasone disodium phosphate is more effective in delivering dexamethasone into the subretinal fluid of patients with a rhegmatogenous retinal detachment compared with peribulbar injection or oral administration. The subretinal dexamethasone concentrations were higher than concentrations measured in the vitreous in previous studies with a similar setup after all three delivery methods. (C) 2000 American Academy of Ophthalmology.
UR - http://www.scopus.com/inward/record.url?scp=0033782221&partnerID=8YFLogxK
U2 - 10.1016/S0161-6420(00)00344-4
DO - 10.1016/S0161-6420(00)00344-4
M3 - Article
C2 - 11013202
AN - SCOPUS:0033782221
SN - 0161-6420
VL - 107
SP - 1932
EP - 1938
JO - Ophthalmology
JF - Ophthalmology
IS - 10
ER -