TY - JOUR
T1 - Development, wiring and function of dopamine neuron subtypes
AU - Garritsen, Oxana
AU - van Battum, Eljo Y.
AU - Grossouw, Laurens M.
AU - Pasterkamp, R. Jeroen
N1 - Funding Information:
The authors thank P. Lingor for input on the manuscript. Work on the dopamine system in the laboratory of the authors is supported by Stichting Parkinson Fonds, the Dutch Research Council (NWO; ALW-VICI 865.14.004) and the NWO Gravitation programme BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (NWO: 024.004.012) to R.J.P. The authors apologize to all investigators whose research could not be appropriately cited owing to space limitations.
Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/3
Y1 - 2023/3
N2 - The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
AB - The midbrain dopamine (mDA) system is composed of molecularly and functionally distinct neuron subtypes that mediate specific behaviours and are linked to various brain diseases. Considerable progress has been made in identifying mDA neuron subtypes, and recent work has begun to unveil how these neuronal subtypes develop and organize into functional brain structures. This progress is important for further understanding the disparate physiological functions of mDA neurons and their selective vulnerability in disease, and will ultimately accelerate therapy development. This Review discusses recent advances in our understanding of molecularly defined mDA neuron subtypes and their circuits, ranging from early developmental events, such as neuron migration and axon guidance, to their wiring and function, and future implications for therapeutic strategies.
UR - http://www.scopus.com/inward/record.url?scp=85146392022&partnerID=8YFLogxK
U2 - 10.1038/s41583-022-00669-3
DO - 10.1038/s41583-022-00669-3
M3 - Review article
AN - SCOPUS:85146392022
SN - 1471-003X
VL - 24
SP - 134
EP - 152
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 3
ER -