Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media

D Bogaert; Emma Holmlund; Mika Lahdenkari; Ronald De Groot; Terhi Kilpi; Peter W M Hermans; Helena Kayhty

doi:10.1111/j.1574-695X.2005.00012.x

Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media

D Bogaert, Emma Holmlund, Mika Lahdenkari, Ronald De Groot, Terhi Kilpi, Peter W M Hermans^*, Helena Kayhty

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

Abstract

The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).

Original language	English
Pages (from-to)	166-168
Number of pages	3
Journal	FEMS Immunology and Medical Microbiology
Volume	46
Issue number	2
DOIs	https://doi.org/10.1111/j.1574-695X.2005.00012.x
Publication status	Published - Mar 2006

Keywords

Acute otitis media
PpmA
Streptococcus pneumoniae

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abstract = "The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).",

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AU - De Groot, Ronald

AU - Kilpi, Terhi

AU - Hermans, Peter W M

AU - Kayhty, Helena

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AB - The putative pneumococcal proteinase maturation protein A is a potential pneumococcal vaccine candidate. We examined serum antipneumococcal proteinase maturation protein A antibodies at 6, 12, 18 and 24 months of age, and showed that the age-related development of antipneumococcal proteinase maturation protein A antibodies is associated with pneumococcal contacts. A higher antipneumococcal proteinase maturation protein A antibody concentration at 18 months of age tends to predict for a lower risk of pneumococcal acute otitis media in the following 6 months (relative risk: 0.84, 95% confidence interval: 0.62-1.13).

KW - Acute otitis media

KW - PpmA

KW - Streptococcus pneumoniae

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Development of antibodies against the putative proteinase maturation protein A in relation to pneumococcal carriage and otitis media

Abstract

Keywords

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