Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

Meike de Wit; Evelien Dekker; Manon Spaander; Monique van Leerdam; Veerle Coupe; Gerrit Meijer; Beatriz Carvalho

doi:10.1007/s10620-025-08919-x

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

Meike de Wit
, Evelien Dekker
, Manon Spaander
, Monique van Leerdam
, Veerle Coupe
, Gerrit Meijer
, Beatriz Carvalho^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

Original language	English
Pages (from-to)	1683-1693
Number of pages	11
Journal	Digestive Diseases and Sciences
Volume	70
Issue number	5
Early online date	15 Apr 2025
DOIs	https://doi.org/10.1007/s10620-025-08919-x
Publication status	Published - May 2025

Keywords

Biomarker development
CRC screening
Fecal immunochemical test (FIT)
Multitarget fecal immunochemical test (mtFIT)

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10.1007/s10620-025-08919-xLicence: CC BY-NC

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)Final published version, 1.56 MBLicence: CC BY-NC

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title = "Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)",

abstract = "Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.",

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AU - de Wit, Meike

AU - Dekker, Evelien

AU - Spaander, Manon

AU - van Leerdam, Monique

AU - Coupe, Veerle

AU - Meijer, Gerrit

AU - Carvalho, Beatriz

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/5

Y1 - 2025/5

N2 - Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

AB - Early detection of colorectal cancer (CRC) through screening is the most effective method to reduce morbidity as well as mortality from this disease. Fecal immunochemical test (FIT)-based screening has shown to be effective, especially in multi-round population-based screening. However, its sensitivity and specificity are suboptimal, leaving room for improvement. In this perspective, the development journey of a new screening test, the multitargetFIT (mtFIT), which outperforms FIT, is described from discovery down to large-scale clinical utility testing and health technology assessment.

KW - Biomarker development

KW - CRC screening

KW - Fecal immunochemical test (FIT)

KW - Multitarget fecal immunochemical test (mtFIT)

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SN - 0163-2116

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JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

IS - 5

ER -

Developing a New Stool Test for Colorectal Cancer Screening, the multitargetFIT (mtFIT)

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