TY - JOUR
T1 - Determinants of Physical Activity among Patients with Colorectal Cancer
T2 - From Diagnosis to 5 Years after Diagnosis
AU - Smit, Karel C
AU - Derksen, Jeroen W G
AU - Stellato, Rebecca K
AU - van Lanen, Anne-Sophie
AU - Wesselink, Evertine
AU - Belt, Eric J Th
AU - Cloos-van Balen, Marissa
AU - Coene, Peter Paul L O
AU - Dekker, Jan Willem T
AU - de Groot, Jan Willem
AU - Haringhuizen, Annebeth W
AU - van Halteren, Henk K
AU - van Heek, Tjarda T
AU - Helgason, Helgi H
AU - Hendriks, Mathijs P
AU - de Hingh, Ignace H J T
AU - Hoekstra, Ronald
AU - Houtsma, Danny
AU - Janssen, Johan J B
AU - Kok, Niels
AU - Konsten, Joop L M
AU - Los, Maartje
AU - Meijerink, Martijn R
AU - Mekenkamp, Leonie J M
AU - Peeters, Koen C M J
AU - Polée, Marco B
AU - Rietbroek, Ron C
AU - Schiphorst, Anandi H W
AU - Schrauwen, Ruud W M
AU - Schreinemakers, Jennifer
AU - Sie, Mark P S
AU - Simkens, Lieke
AU - Sonneveld, Eric J A
AU - Terheggen, Frederiek
AU - Valkenburg-van Iersel, Liselot
AU - Vles, Wouter J
AU - Wasowicz-Kemps, Daria K
AU - de Wilt, Johannes H W
AU - Kok, Dieuwertje E
AU - Winkels, Renate M
AU - Kampman, Ellen
AU - van Duijnhoven, Fränzel J B
AU - Koopman, Miriam
AU - May, Anne M
N1 - Publisher Copyright:
© 2024 Lippincott Williams and Wilkins. All rights reserved.
PY - 2024/4/1
Y1 - 2024/4/1
N2 - Introduction Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis.Methods Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population.Results In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6.Conclusions Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.
AB - Introduction Physical activity (PA) is associated with higher quality of life and probably better prognosis among colorectal cancer (CRC) patients. This study focuses on determinants of PA among CRC patients from diagnosis until 5 yr postdiagnosis.Methods Sociodemographic and disease-related factors of participants of two large CRC cohort studies were combined. Moderate-to-vigorous PA during sport and leisure time (MVPA-SL) was measured at diagnosis (T0) and 6, 12, 24, and 60 months (T6 to T60) postdiagnosis, using the SQUASH questionnaire. Mixed-effects models were performed to identify sociodemographic and disease-related determinants of MVPA-SL, separately for stage I–III colon (CC), stage I–III rectal cancer (RC), and stage IV CRC (T0 and T6 only). Associations were defined as consistently present when significant at ≥4 timepoints for the stage I–III subsets. MVPA-SL levels were compared with an age- and sex-matched sample of the general Dutch population.Results In total, 2905 CC, 1459 RC and 436 stage IV CRC patients were included. Patients with higher fatigue scores, and women compared with men had consistently lower MVPA-SL levels over time, regardless of tumor type and stage. At T6, having a stoma was significantly associated with lower MVPA-SL among stage I-III RC patients. Systemic therapy and radiotherapy were not significantly associated with MVPA-SL changes at T6. Compared with the general population, MVPA-SL levels of CRC patients were lower at all timepoints, most notably at T6.Conclusions Female sex and higher fatigue scores were consistent determinants of lower MVPA-SL levels among all CRC patients, and MVPA-SL levels were lowest at 6 months postdiagnosis. Our results can inform the design of intervention studies aimed at improving PA, and guide healthcare professionals in optimizing individualized support.
KW - COLORECTAL NEOPLASMS
KW - GUIDELINES
KW - HEALTH BEHAVIOR
KW - SPORT PARTICIPATION
KW - SURVIVORSHIP
UR - http://www.scopus.com/inward/record.url?scp=85187958266&partnerID=8YFLogxK
U2 - 10.1249/MSS.0000000000003351
DO - 10.1249/MSS.0000000000003351
M3 - Article
C2 - 38079324
SN - 0195-9131
VL - 56
SP - 623
EP - 634
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 4
M1 - 10.1249/MSS.0000000000003351
ER -