Determinants of patient's and doctor's delay in diagnosis and treatment of colorectal cancer

A.M. van Hout, N.J. de Wit, F.H. Rutten, P.H.M. Peeters

Research output: Contribution to journalArticleAcademicpeer-review

28 Citations (Scopus)


Background: Early detection and treatment is important for the management of colorectal cancer (CRC). Aim: To assess patient and doctor delay and their determinants. Methods: A retrospective observational study in a primary care setting concerning 197 patients with CRC. The time between initial symptoms and the onset of treatment was categorized into four periods. With multivariable logistic regression analysis, determinants of delay were investigated. Results: The median time from onset of symptoms until the start of treatment was 138 days. Median time for the four periods to: first general practitioner consult, first specialist consult, histological diagnosis, and start treatment were 30, 14, 27, and 18 days, respectively. Rectal blood loss and weight loss were significantly related to patient delay, whereas psychiatric comorbidity was related to delay in referral by the general practitioner. For delay in histological diagnosis and start of definitive treatment no determinants were found. Delay was not associated with more advanced disease stages. Conclusion: There is considerable delay in the management of CRC, especially in time to consultation and time to onset of clinical treatment. Education among the general public about the importance of alarm symptoms and increasing efficiency of the diagnostic process in hospital setting are a key in improving CRC disease management.

Original languageEnglish
Pages (from-to)1056-1063
Number of pages8
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number11
Publication statusPublished - Nov 2011


  • colorectal cancer
  • doctor's delay
  • general practice
  • patient's delay


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