Determinants of first trimester combined test participation within the central region of the Netherlands

Neeltje M. T. H. Crombag; Peter C. J. I. Schielen; Chantal W. Hukkelhoven; Rita Iedema; Jozien M. Bensing; Gerard H. A. Visser; Philip Stoutenbeek; Maria P. H. Koster; M.P.H. (Wendy) Koster

doi:10.1002/pd.4564

Determinants of first trimester combined test participation within the central region of the Netherlands

Neeltje M. T. H. Crombag^*, Peter C. J. I. Schielen, Chantal W. Hukkelhoven, Rita Iedema, Jozien M. Bensing, Gerard H. A. Visser, Philip Stoutenbeek, Maria P. H. Koster, M.P.H. (Wendy) Koster

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

ObjectiveOur objective is to study the association between potentially influential determinants and first-trimester combined test (FCT) uptake rates in the central region of the Netherlands.

MethodsData were extracted from the national prenatal screening database Peridos and the Netherlands Perinatal Registry and compared at the level of the health care provider. Univariable and multivariable linear regression analysis was used to determine the effect of determinants (maternal age, parity, socio-economic status (SES), mode of conception, ethnicity and urbanisation) on uptake.

ResultsPrenatal screening data were available for 24657 women and overall uptake rate was 25.7%. The strongest association with FCT uptake was found for advanced maternal age ( 2.2; 95% CI [1.7, 2.8]). Grand multiparity had a significantly negative association with FCT uptake ( -4.3; 95% CI [-5.9, -2.7]). Positive associations were found for very high urbanisation ( 0.3; 95% CI [0.1, 0.4]) and high SES ( 0.2; 95% CI [0.0, 0.3]).

ConclusionAdvanced maternal age is strongly associated with participation in prenatal testing. The role of age related risk perception should be incorporated in future policy making to support women in informed and autonomous decision making. The negative association of grand multiparity and FCT might be religion based but requires further research. (c) 2015 John Wiley & Sons, Ltd.

Original language	English
Pages (from-to)	486-492
Number of pages	7
Journal	Prenatal Diagnosis
Volume	35
Issue number	5
DOIs	https://doi.org/10.1002/pd.4564
Publication status	Published - May 2015

Keywords

DOWN-SYNDROME
TERMINATION
DECISIONS
DEFECTS
IMPACT
RATES
WOMEN

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10.1002/pd.4564

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@article{0c9c7440e7eb47688c87e21d0d9a2b37,

title = "Determinants of first trimester combined test participation within the central region of the Netherlands",

abstract = "ObjectiveOur objective is to study the association between potentially influential determinants and first-trimester combined test (FCT) uptake rates in the central region of the Netherlands.MethodsData were extracted from the national prenatal screening database Peridos and the Netherlands Perinatal Registry and compared at the level of the health care provider. Univariable and multivariable linear regression analysis was used to determine the effect of determinants (maternal age, parity, socio-economic status (SES), mode of conception, ethnicity and urbanisation) on uptake.ResultsPrenatal screening data were available for 24657 women and overall uptake rate was 25.7%. The strongest association with FCT uptake was found for advanced maternal age ( 2.2; 95% CI [1.7, 2.8]). Grand multiparity had a significantly negative association with FCT uptake ( -4.3; 95% CI [-5.9, -2.7]). Positive associations were found for very high urbanisation ( 0.3; 95% CI [0.1, 0.4]) and high SES ( 0.2; 95% CI [0.0, 0.3]).ConclusionAdvanced maternal age is strongly associated with participation in prenatal testing. The role of age related risk perception should be incorporated in future policy making to support women in informed and autonomous decision making. The negative association of grand multiparity and FCT might be religion based but requires further research. (c) 2015 John Wiley & Sons, Ltd.",

keywords = "DOWN-SYNDROME, TERMINATION, DECISIONS, DEFECTS, IMPACT, RATES, WOMEN",

author = "Crombag, {Neeltje M. T. H.} and Schielen, {Peter C. J. I.} and Hukkelhoven, {Chantal W.} and Rita Iedema and Bensing, {Jozien M.} and Visser, {Gerard H. A.} and Philip Stoutenbeek and Koster, {Maria P. H.} and Koster, {M.P.H. (Wendy)}",

year = "2015",

month = may,

doi = "10.1002/pd.4564",

language = "English",

volume = "35",

pages = "486--492",

journal = "Prenatal Diagnosis",

issn = "0197-3851",

publisher = "John Wiley & Sons Inc.",

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T1 - Determinants of first trimester combined test participation within the central region of the Netherlands

AU - Crombag, Neeltje M. T. H.

AU - Schielen, Peter C. J. I.

AU - Hukkelhoven, Chantal W.

AU - Iedema, Rita

AU - Bensing, Jozien M.

AU - Visser, Gerard H. A.

AU - Stoutenbeek, Philip

AU - Koster, Maria P. H.

AU - Koster, M.P.H. (Wendy)

PY - 2015/5

Y1 - 2015/5

N2 - ObjectiveOur objective is to study the association between potentially influential determinants and first-trimester combined test (FCT) uptake rates in the central region of the Netherlands.MethodsData were extracted from the national prenatal screening database Peridos and the Netherlands Perinatal Registry and compared at the level of the health care provider. Univariable and multivariable linear regression analysis was used to determine the effect of determinants (maternal age, parity, socio-economic status (SES), mode of conception, ethnicity and urbanisation) on uptake.ResultsPrenatal screening data were available for 24657 women and overall uptake rate was 25.7%. The strongest association with FCT uptake was found for advanced maternal age ( 2.2; 95% CI [1.7, 2.8]). Grand multiparity had a significantly negative association with FCT uptake ( -4.3; 95% CI [-5.9, -2.7]). Positive associations were found for very high urbanisation ( 0.3; 95% CI [0.1, 0.4]) and high SES ( 0.2; 95% CI [0.0, 0.3]).ConclusionAdvanced maternal age is strongly associated with participation in prenatal testing. The role of age related risk perception should be incorporated in future policy making to support women in informed and autonomous decision making. The negative association of grand multiparity and FCT might be religion based but requires further research. (c) 2015 John Wiley & Sons, Ltd.

AB - ObjectiveOur objective is to study the association between potentially influential determinants and first-trimester combined test (FCT) uptake rates in the central region of the Netherlands.MethodsData were extracted from the national prenatal screening database Peridos and the Netherlands Perinatal Registry and compared at the level of the health care provider. Univariable and multivariable linear regression analysis was used to determine the effect of determinants (maternal age, parity, socio-economic status (SES), mode of conception, ethnicity and urbanisation) on uptake.ResultsPrenatal screening data were available for 24657 women and overall uptake rate was 25.7%. The strongest association with FCT uptake was found for advanced maternal age ( 2.2; 95% CI [1.7, 2.8]). Grand multiparity had a significantly negative association with FCT uptake ( -4.3; 95% CI [-5.9, -2.7]). Positive associations were found for very high urbanisation ( 0.3; 95% CI [0.1, 0.4]) and high SES ( 0.2; 95% CI [0.0, 0.3]).ConclusionAdvanced maternal age is strongly associated with participation in prenatal testing. The role of age related risk perception should be incorporated in future policy making to support women in informed and autonomous decision making. The negative association of grand multiparity and FCT might be religion based but requires further research. (c) 2015 John Wiley & Sons, Ltd.

KW - DOWN-SYNDROME

KW - TERMINATION

KW - DECISIONS

KW - DEFECTS

KW - IMPACT

KW - RATES

KW - WOMEN

U2 - 10.1002/pd.4564

DO - 10.1002/pd.4564

M3 - Article

C2 - 25613681

SN - 0197-3851

VL - 35

SP - 486

EP - 492

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 5

ER -

Determinants of first trimester combined test participation within the central region of the Netherlands

Abstract

Keywords

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