TY - JOUR
T1 - Detection of Incident Anal High-Risk Hpv-Dna in Msm
T2 - Incidence or Reactivation?
AU - Twisk, Denise E
AU - van der Sande, Marianne A B
AU - van Eeden, Arne
AU - Heideman, Daniëlle A M
AU - van der Klis, Fiona R M
AU - de Vries, Henry J C
AU - Schim van der Loeff, Maarten F
PY - 2018/8/24
Y1 - 2018/8/24
N2 - Background: We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM).Methods: A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system. Serum samples were tested for high-risk (hr)HPV antibodies. Incident anal HPV detection rates among sexually non-, low and highly exposed MSM were compared. Factors associated with incident anal hrHPV detection were assessed using multivariable Cox regression.Results: 714 men (median age 40 years; 39% HIV positive) were included in the analysis. Incident anal detections of all hrHPV-types were observed among both sexually non-exposed and exposed MSM. In multivariable analyses, highly sexually exposed, being HIV-infected and having a penile HPV infection were positively associated with incident anal HPV detection; those reporting more sex partners had a non-significantly increased risk of HPV detection.Conclusion: Incident anal hrHPV detection is common among recently non-exposed MSM, suggesting that a reactivated latent HPV infection instead of an incident infection may underlie incident HPV detection.
AB - Background: We aimed to assess whether sexual exposure may explain all incident anal HPV detections among men who have sex with men (MSM).Methods: A longitudinal study among MSM was conducted between 2010 and 2013 with six-monthly visits and up to 24 months of follow-up. Risk-factor questionnaires, blood samples, and anal and penile self-swabs were collected at each visit. Self-swabs were used for detection and genotyping of HPV by SPF10-PCR/DEIA/LiPA25 system. Serum samples were tested for high-risk (hr)HPV antibodies. Incident anal HPV detection rates among sexually non-, low and highly exposed MSM were compared. Factors associated with incident anal hrHPV detection were assessed using multivariable Cox regression.Results: 714 men (median age 40 years; 39% HIV positive) were included in the analysis. Incident anal detections of all hrHPV-types were observed among both sexually non-exposed and exposed MSM. In multivariable analyses, highly sexually exposed, being HIV-infected and having a penile HPV infection were positively associated with incident anal HPV detection; those reporting more sex partners had a non-significantly increased risk of HPV detection.Conclusion: Incident anal hrHPV detection is common among recently non-exposed MSM, suggesting that a reactivated latent HPV infection instead of an incident infection may underlie incident HPV detection.
KW - HPV
KW - HIV
KW - incidence rate
KW - men who have sex with men
KW - latency
U2 - 10.1093/infdis/jiy276
DO - 10.1093/infdis/jiy276
M3 - Article
C2 - 29771378
SN - 0022-1899
VL - 218
SP - 1018
EP - 1026
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -