Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

Max H M C Scheepers; Zaid J J Al-Difaie; Anne G W E Wintjens; Sanne M E Engelen; Bas Havekes; Tim Lubbers; Marielle M E Coolsen; Job van der Palen; Tessa M van Ginhoven; Menno Vriens; Nicole D Bouvy

doi:10.1088/1752-7163/ac77a9

Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

Max H M C Scheepers, Zaid J J Al-Difaie, Anne G W E Wintjens, Sanne M E Engelen, Bas Havekes, Tim Lubbers, Marielle M E Coolsen, Job van der Palen, Tessa M van Ginhoven, Menno Vriens, Nicole D Bouvy

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Abstract

This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Breath samples were analyzed utilizing artificial neural networking. About 133 participants were included, 48 of whom were diagnosed with well-differentiated thyroid cancer. A sensitivity of 0.73 and a negative predictive value (NPV) of 0.82 were found. The sensitivity and NPV improved to 0.94 and 0.95 respectively after adding clinical variables via multivariate logistic regression analysis. This study demonstrates the feasibility of the Aeonose to discriminate between malignant and benign thyroid disease. With a high NPV, low cost, and non-invasive nature, the Aeonose may be a promising diagnostic tool in the detection of thyroid cancer.

Original language	English
Article number	036008
Journal	Journal of Breath Research
Volume	16
Issue number	3
DOIs	https://doi.org/10.1088/1752-7163/ac77a9
Publication status	Published - 21 Jun 2022

Keywords

Breath Tests
Electronic Nose
Exhalation
Humans
Thyroid Neoplasms/diagnosis
Volatile Organic Compounds/analysis
thyroid carcinoma
volatile organic compounds
electronic nose
exhaled air
innovative diagnostics

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Scheepers_2022_J._Breath_Res._16_036008Final published version, 932 KBLicence: CC BY

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Scheepers, M. H. M. C., Al-Difaie, Z. J. J., Wintjens, A. G. W. E., Engelen, S. M. E., Havekes, B., Lubbers, T., Coolsen, M. M. E., van der Palen, J., van Ginhoven, T. M., Vriens, M., & Bouvy, N. D. (2022). Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose. Journal of Breath Research, 16(3), Article 036008. https://doi.org/10.1088/1752-7163/ac77a9

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abstract = "This proof-of-principle study investigates the diagnostic performance of the Aeonose in differentiating malignant from benign thyroid diseases based on volatile organic compound analysis in exhaled breath. All patients with a suspicious thyroid nodule planned for surgery, exhaled in the Aeonose. Definitive diagnosis was provided by histopathological determination after surgical resection. Breath samples were analyzed utilizing artificial neural networking. About 133 participants were included, 48 of whom were diagnosed with well-differentiated thyroid cancer. A sensitivity of 0.73 and a negative predictive value (NPV) of 0.82 were found. The sensitivity and NPV improved to 0.94 and 0.95 respectively after adding clinical variables via multivariate logistic regression analysis. This study demonstrates the feasibility of the Aeonose to discriminate between malignant and benign thyroid disease. With a high NPV, low cost, and non-invasive nature, the Aeonose may be a promising diagnostic tool in the detection of thyroid cancer.",

keywords = "Breath Tests, Electronic Nose, Exhalation, Humans, Thyroid Neoplasms/diagnosis, Volatile Organic Compounds/analysis, thyroid carcinoma, volatile organic compounds, electronic nose, exhaled air, innovative diagnostics",

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AU - Bouvy, Nicole D

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Detection of differentiated thyroid carcinoma in exhaled breath with an electronic nose

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