Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

F.A. Verburg; C.J.M. Lips; E.G.W.M. Lentjes; J.M.H. de Klerk

doi:10.1038/sj.bjc.6601991

Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

F.A. Verburg, C.J.M. Lips, E.G.W.M. Lentjes, J.M.H. de Klerk

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.

Original language	English
Pages (from-to)	200-204
Number of pages	5
Journal	British Journal of Cancer
Volume	91
Issue number	2
DOIs	https://doi.org/10.1038/sj.bjc.6601991
Publication status	Published - 2004

Keywords

Econometric and Statistical Methods: General
Geneeskunde(GENK)
Bescherming en bevordering van de menselijke gezondheid
Other medical specialities

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10.1038/sj.bjc.6601991

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title = "Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?",

abstract = "To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.",

keywords = "Econometric and Statistical Methods: General, Geneeskunde(GENK), Bescherming en bevordering van de menselijke gezondheid, Other medical specialities",

author = "F.A. Verburg and C.J.M. Lips and E.G.W.M. Lentjes and \{de Klerk\}, J.M.H.",

year = "2004",

doi = "10.1038/sj.bjc.6601991",

language = "English",

volume = "91",

pages = "200--204",

journal = "British Journal of Cancer",

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T2 - how useful is it?

AU - Verburg, F.A.

AU - Lips, C.J.M.

AU - Lentjes, E.G.W.M.

AU - de Klerk, J.M.H.

PY - 2004

Y1 - 2004

N2 - To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.

AB - To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.

KW - Econometric and Statistical Methods: General

KW - Geneeskunde(GENK)

KW - Bescherming en bevordering van de menselijke gezondheid

KW - Other medical specialities

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DO - 10.1038/sj.bjc.6601991

M3 - Article

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SN - 0007-0920

VL - 91

SP - 200

EP - 204

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 2

ER -

Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

Abstract

Keywords

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