Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?

F.A. Verburg, C.J.M. Lips, E.G.W.M. Lentjes, J.M.H. de Klerk

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalBritish Journal of Cancer
Volume91
Issue number2
DOIs
Publication statusPublished - 2004

Keywords

  • Econometric and Statistical Methods: General
  • Geneeskunde(GENK)
  • Bescherming en bevordering van de menselijke gezondheid
  • Other medical specialities

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