TY - JOUR
T1 - Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI
T2 - The SMART-MR study
AU - Ghaznawi, Rashid
AU - de Bresser, Jeroen
AU - van der Graaf, Yolanda
AU - Zwartbol, Maarten H.T.
AU - Witkamp, Theo D.
AU - Geerlings, Mirjam I.
AU - Hendrikse, Jeroen
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Funding for this paper was received as part of a grant from the Netherlands Organization for Scientific Research-Medical Sciences (NWO-MW: project No. 904-65-095). This funding source had no role in the design, data collection, data analyses and data interpretation of the study or writing of the report. We also gratefully acknowledge the funding from the European Research Council under the European Union’s Horizon 2020 Programme (H2020) / ERC grant agreement n°637024 and n°66681 (SVDs@target).
Funding Information:
We gratefully acknowledge the contribution of the SMART research personnel: R van Petersen and BGF. Dinther and also the participants of the SMART Study Group: A. Algra MD, PhD; Y van der Graaf, MD, PhD; D.E. Grobbee, MD, PhD; G.E.H.M. Rutten, MD, PhD, Julius Center for Health Sciences and Primary care; FLJ Visseren, MD, PhD, Department of Internal Medicine; GJ de Borst, MD, PhD, Department of Vascular Surgery; LJ Kappelle, MD, PhD, Department of Neurology; T Leiner, MD, PhD, Department of Radiology; PA Doevendans, MD, PhD, Department of Cardiology.
Publisher Copyright:
© The Author(s) 2017.
PY - 2018/9
Y1 - 2018/9
N2 - Small infarcts are among the key imaging features of cerebral small vessel disease (CSVD), but remain largely undetected on conventional MRI. We aimed to evaluate (1) imaging criteria for the detection of small infarcts in the caudate nucleus on 7T MRI, (2) intra- and inter-rater agreement, (3) frequency and (4) detection rate on 7T versus 1.5T MRI. In 90 patients (68 ± 8 years) with a history of vascular disease from the SMART-MR study, we defined 7T imaging criteria for cavitated and non-cavitated small infarcts in the caudate nucleus. In a separate set of 23 patients from the SMART study, intra-rater and inter-rater agreement was excellent for presence, number, and individual locations (Kappa’s, ICCs, and Dice similarity coefficients ranged from 0.85 to 1.00). In the 90 patients, 21 infarcts (20 cavitated) in 12 patients were detected on 7T (13%) compared to 7 infarcts in 6 patients on 1.5T (7%). In conclusion, we established reproducible imaging criteria for the detection of small infarcts in the caudate nucleus on 7T MRI and showed that 7T MRI allows for a higher detection rate than conventional 1.5T MRI. These imaging criteria can be used in future studies to provide new insights into the pathophysiology of CSVD.
AB - Small infarcts are among the key imaging features of cerebral small vessel disease (CSVD), but remain largely undetected on conventional MRI. We aimed to evaluate (1) imaging criteria for the detection of small infarcts in the caudate nucleus on 7T MRI, (2) intra- and inter-rater agreement, (3) frequency and (4) detection rate on 7T versus 1.5T MRI. In 90 patients (68 ± 8 years) with a history of vascular disease from the SMART-MR study, we defined 7T imaging criteria for cavitated and non-cavitated small infarcts in the caudate nucleus. In a separate set of 23 patients from the SMART study, intra-rater and inter-rater agreement was excellent for presence, number, and individual locations (Kappa’s, ICCs, and Dice similarity coefficients ranged from 0.85 to 1.00). In the 90 patients, 21 infarcts (20 cavitated) in 12 patients were detected on 7T (13%) compared to 7 infarcts in 6 patients on 1.5T (7%). In conclusion, we established reproducible imaging criteria for the detection of small infarcts in the caudate nucleus on 7T MRI and showed that 7T MRI allows for a higher detection rate than conventional 1.5T MRI. These imaging criteria can be used in future studies to provide new insights into the pathophysiology of CSVD.
KW - 7 tesla MRI
KW - Brain
KW - cerebral infarcts
KW - cerebrovascular disease
KW - magnetic resonance imaging
KW - small vessel disease
UR - http://www.scopus.com/inward/record.url?scp=85046030094&partnerID=8YFLogxK
U2 - 10.1177/0271678X17705974
DO - 10.1177/0271678X17705974
M3 - Article
C2 - 28436255
SN - 0271-678X
VL - 38
SP - 1609
EP - 1617
JO - Journal of Cerebral Blood Flow and Metabolism
JF - Journal of Cerebral Blood Flow and Metabolism
IS - 9
ER -