Detecting "different": Pyrin senses modified GTPases

Marcel R de Zoete; Richard A Flavell

doi:10.1038/cr.2014.101

Detecting "different": Pyrin senses modified GTPases

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.

Original language	English
Pages (from-to)	1286-7
Number of pages	2
Journal	Cell Research
Volume	24
Issue number	11
DOIs	https://doi.org/10.1038/cr.2014.101
Publication status	Published - Nov 2014
Externally published	Yes

Keywords

Animals
Cytoskeletal Proteins/metabolism
Humans
Immunity, Innate/immunology
Inflammasomes/metabolism
rho GTP-Binding Proteins/metabolism

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10.1038/cr.2014.101

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title = "Detecting {"}different{"}: Pyrin senses modified GTPases",

abstract = "Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process. ",

keywords = "Animals, Cytoskeletal Proteins/metabolism, Humans, Immunity, Innate/immunology, Inflammasomes/metabolism, rho GTP-Binding Proteins/metabolism",

author = "{de Zoete}, {Marcel R} and Flavell, {Richard A}",

year = "2014",

month = nov,

doi = "10.1038/cr.2014.101",

language = "English",

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AU - Flavell, Richard A

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AB - Pathogenic bacteria secrete effector proteins that target host cell Rho GTPases to manipulate the actin cytoskeleton. A recent study in Nature identifies the Pyrin inflammasome as a sensor of this pathogenic process.

KW - Animals

KW - Cytoskeletal Proteins/metabolism

KW - Humans

KW - Immunity, Innate/immunology

KW - Inflammasomes/metabolism

KW - rho GTP-Binding Proteins/metabolism

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DO - 10.1038/cr.2014.101

M3 - Article

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VL - 24

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EP - 1287

JO - Cell Research

JF - Cell Research

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Detecting "different": Pyrin senses modified GTPases

Abstract

Keywords

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