Desmoplastic infantile ganglioglioma with a malignant course

Eelco W Hoving; Johan M Kros; Ellis Groninger; Wilfred F A den Dunnen

doi:10.3171/PED-08/01/095

Desmoplastic infantile ganglioglioma with a malignant course

Eelco W Hoving, Johan M Kros, Ellis Groninger, Wilfred F A den Dunnen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

Original language	English
Pages (from-to)	95-8
Number of pages	4
Journal	Journal of Neurosurgery: Pediatrics
Volume	1
Issue number	1
DOIs	https://doi.org/10.3171/PED-08/01/095
Publication status	Published - Jan 2008

Keywords

Ganglioglioma/metabolism
Glial Fibrillary Acidic Protein/metabolism
Humans
Infant
Ki-67 Antigen/metabolism
Magnetic Resonance Imaging
Male
Neoplasm Recurrence, Local
Neoplasm Staging
Neurosurgical Procedures/methods
Supratentorial Neoplasms/metabolism
Ubiquitin-Protein Ligases/metabolism

Access to Document

10.3171/PED-08/01/095

Cite this

@article{eed496270e234e199dcb58b454575141,

title = "Desmoplastic infantile ganglioglioma with a malignant course",

abstract = "Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.",

keywords = "Ganglioglioma/metabolism, Glial Fibrillary Acidic Protein/metabolism, Humans, Infant, Ki-67 Antigen/metabolism, Magnetic Resonance Imaging, Male, Neoplasm Recurrence, Local, Neoplasm Staging, Neurosurgical Procedures/methods, Supratentorial Neoplasms/metabolism, Ubiquitin-Protein Ligases/metabolism",

author = "Hoving, {Eelco W} and Kros, {Johan M} and Ellis Groninger and {den Dunnen}, {Wilfred F A}",

year = "2008",

month = jan,

doi = "10.3171/PED-08/01/095",

language = "English",

volume = "1",

pages = "95--8",

journal = "Journal of Neurosurgery: Pediatrics",

issn = "1933-0707",

publisher = "American Association of Neurological Surgeons",

number = "1",

}

TY - JOUR

T1 - Desmoplastic infantile ganglioglioma with a malignant course

AU - Hoving, Eelco W

AU - Kros, Johan M

AU - Groninger, Ellis

AU - den Dunnen, Wilfred F A

PY - 2008/1

Y1 - 2008/1

N2 - Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

AB - Desmoplastic infantile gangliogliomas (DIGs) are rare supratentorial tumors that arise in infancy. Despite the large size of these lesions, the prognosis is generally considered favorable after gross-total resection (GTR); however, in incidental cases tumor progression has been described. The authors report on a child harboring a DIG with a high-grade primitive cell population and glial differentiation. The progressive clinical course was determined by this cell component in spite of GTR and adjuvant chemotherapy. The significance of the presence of a high-grade primitive tumor component in the context of DIG is discussed.

KW - Ganglioglioma/metabolism

KW - Glial Fibrillary Acidic Protein/metabolism

KW - Humans

KW - Infant

KW - Ki-67 Antigen/metabolism

KW - Magnetic Resonance Imaging

KW - Male

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Neurosurgical Procedures/methods

KW - Supratentorial Neoplasms/metabolism

KW - Ubiquitin-Protein Ligases/metabolism

U2 - 10.3171/PED-08/01/095

DO - 10.3171/PED-08/01/095

M3 - Article

C2 - 18352812

SN - 1933-0707

VL - 1

SP - 95

EP - 98

JO - Journal of Neurosurgery: Pediatrics

JF - Journal of Neurosurgery: Pediatrics

IS - 1

ER -

Desmoplastic infantile ganglioglioma with a malignant course

Abstract

Keywords

Access to Document

Fingerprint

Cite this