TY - JOUR
T1 - Designing pragmatic trials—what can we learn from lessons learned?
AU - Groenwold, Rolf H.H.
AU - Dekkers, Olaf M
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Pragmatic trials aim to inform clinical decision making by measuring the effect of a treatment in clinical practice. The purpose of the PRECIS-2 tool is to support in designing a truly pragmatic trial. We comment on a study by Forbes et al., who assessed the applicability of the PRECIS-2 tool. The tool will prove particularly useful when implemented in the process of trial design. However, it is yet unclear how e.g., possible dependencies between PRECIS domains, or conducting a pragmatic trial within an existing data registry (e.g., electronic health records) affect the applicability of the tool.
AB - Pragmatic trials aim to inform clinical decision making by measuring the effect of a treatment in clinical practice. The purpose of the PRECIS-2 tool is to support in designing a truly pragmatic trial. We comment on a study by Forbes et al., who assessed the applicability of the PRECIS-2 tool. The tool will prove particularly useful when implemented in the process of trial design. However, it is yet unclear how e.g., possible dependencies between PRECIS domains, or conducting a pragmatic trial within an existing data registry (e.g., electronic health records) affect the applicability of the tool.
KW - Pragmatic trial
KW - Randomised trial
UR - http://www.scopus.com/inward/record.url?scp=85021896120&partnerID=8YFLogxK
U2 - 10.1016/j.jclinepi.2017.06.006
DO - 10.1016/j.jclinepi.2017.06.006
M3 - Comment/Letter to the editor
C2 - 28629700
AN - SCOPUS:85021896120
SN - 0895-4356
VL - 90
SP - 3
EP - 5
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -