Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

Ulrike Weirauch; Markus Kreuz; Colin Birkenbihl; Miriam Alb; Maria Quaranta; Laurence Calzone; Sophia Orozco-Ruiz; Stefanie Binder; Luise Fischer; Solène Clavreul; Morine Maguri; Maximilian Ferle; Michael Rade; Guillaume Azarias; Jay R Hydren; Jakub Jamarik; Daniel Schwarz; Zsolt Sebestyen; Jurgen Kuball; Georg Popp; Chloé Antoine; Manon Knockaert; Clara T Schoeder; David Fandrei; Carmen Sanges; Vaclovas Radvilas; Nico Gagelmann; Markus Rückert; Olaf Penack; Stephan Fricke; Andreas Schmidt; Carol Ward; Carl Steinbeisser; Jean-Marc Van Gyseghem; Anna Niarakis; Laurent Garderet; Michael Hudecek; Thomas Neumuth; Uwe Platzbecker; Ulrike Köhl; Regina Demlova; Andreas Kremer; Stefan Franke; Holger Fröhlich; Maximilian Merz; Kristin Reiche

doi:10.1038/s41746-025-01809-6

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

Ulrike Weirauch
, Markus Kreuz
, Colin Birkenbihl
, Miriam Alb
, Maria Quaranta
, Laurence Calzone
, Sophia Orozco-Ruiz
, Stefanie Binder
, Luise Fischer
, Solène Clavreul
, Morine Maguri
, Maximilian Ferle
, Michael Rade
, Guillaume Azarias
, Jay R Hydren
, Jakub Jamarik
, Daniel Schwarz
, Zsolt Sebestyen
, Jurgen Kuball
, Georg Popp

Chloé Antoine, Manon Knockaert, Clara T Schoeder, David Fandrei, Carmen Sanges, Vaclovas Radvilas, Nico Gagelmann, Markus Rückert, Olaf Penack, Stephan Fricke, Andreas Schmidt, Carol Ward, Carl Steinbeisser, Jean-Marc Van Gyseghem, Anna Niarakis, Laurent Garderet, Michael Hudecek, Thomas Neumuth, Uwe Platzbecker, Ulrike Köhl, Regina Demlova, Andreas Kremer, Stefan Franke, Holger Fröhlich, Maximilian Merz, Kristin Reiche^*,

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

34 Downloads (Pure)

Abstract

In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.

Original language	English
Article number	493
Journal	npj digital medicine
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41746-025-01809-6
Publication status	Published - 1 Aug 2025

Access to Document

10.1038/s41746-025-01809-6Licence: CC BY

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapiesFinal published version, 1.94 MBLicence: CC BY

Cite this

Weirauch, U., Kreuz, M., Birkenbihl, C., Alb, M., Quaranta, M., Calzone, L., Orozco-Ruiz, S., Binder, S., Fischer, L., Clavreul, S., Maguri, M., Ferle, M., Rade, M., Azarias, G., Hydren, J. R., Jamarik, J., Schwarz, D., Sebestyen, Z., Kuball, J. (2025). Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies. npj digital medicine, 8(1), Article 493. https://doi.org/10.1038/s41746-025-01809-6

@article{18bee7685ee742e98c98e5a0325dc254,

title = "Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies",

abstract = "In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.",

author = "Ulrike Weirauch and Markus Kreuz and Colin Birkenbihl and Miriam Alb and Maria Quaranta and Laurence Calzone and Sophia Orozco-Ruiz and Stefanie Binder and Luise Fischer and Sol{\`e}ne Clavreul and Morine Maguri and Maximilian Ferle and Michael Rade and Guillaume Azarias and Hydren, \{Jay R\} and Jakub Jamarik and Daniel Schwarz and Zsolt Sebestyen and Jurgen Kuball and Georg Popp and Chlo{\'e} Antoine and Manon Knockaert and Schoeder, \{Clara T\} and David Fandrei and Carmen Sanges and Vaclovas Radvilas and Nico Gagelmann and Markus R{\"u}ckert and Olaf Penack and Stephan Fricke and Andreas Schmidt and Carol Ward and Carl Steinbeisser and \{Van Gyseghem\}, Jean-Marc and Anna Niarakis and Laurent Garderet and Michael Hudecek and Thomas Neumuth and Uwe Platzbecker and Ulrike K{\"o}hl and Regina Demlova and Andreas Kremer and Stefan Franke and Holger Fr{\"o}hlich and Maximilian Merz and Kristin Reiche",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2025.",

year = "2025",

month = aug,

day = "1",

doi = "10.1038/s41746-025-01809-6",

language = "English",

volume = "8",

journal = "npj digital medicine",

issn = "2398-6352",

publisher = "Nature Publishing Group",

number = "1",

}

Weirauch, U, Kreuz, M, Birkenbihl, C, Alb, M, Quaranta, M, Calzone, L, Orozco-Ruiz, S, Binder, S, Fischer, L, Clavreul, S, Maguri, M, Ferle, M, Rade, M, Azarias, G, Hydren, JR, Jamarik, J, Schwarz, D, Sebestyen, Z , Kuball, J, Popp, G, Antoine, C, Knockaert, M, Schoeder, CT, Fandrei, D, Sanges, C, Radvilas, V, Gagelmann, N, Rückert, M, Penack, O, Fricke, S, Schmidt, A, Ward, C, Steinbeisser, C, Van Gyseghem, J-M, Niarakis, A, Garderet, L, Hudecek, M, Neumuth, T, Platzbecker, U, Köhl, U, Demlova, R, Kremer, A, Franke, S, Fröhlich, H, Merz, M, Reiche, K 2025, 'Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies', npj digital medicine, vol. 8, no. 1, 493. https://doi.org/10.1038/s41746-025-01809-6

TY - JOUR

T1 - Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

AU - Weirauch, Ulrike

AU - Kreuz, Markus

AU - Birkenbihl, Colin

AU - Alb, Miriam

AU - Quaranta, Maria

AU - Calzone, Laurence

AU - Orozco-Ruiz, Sophia

AU - Binder, Stefanie

AU - Fischer, Luise

AU - Clavreul, Solène

AU - Maguri, Morine

AU - Ferle, Maximilian

AU - Rade, Michael

AU - Azarias, Guillaume

AU - Hydren, Jay R

AU - Jamarik, Jakub

AU - Schwarz, Daniel

AU - Sebestyen, Zsolt

AU - Kuball, Jurgen

AU - Popp, Georg

AU - Antoine, Chloé

AU - Knockaert, Manon

AU - Schoeder, Clara T

AU - Fandrei, David

AU - Sanges, Carmen

AU - Radvilas, Vaclovas

AU - Gagelmann, Nico

AU - Rückert, Markus

AU - Penack, Olaf

AU - Fricke, Stephan

AU - Schmidt, Andreas

AU - Ward, Carol

AU - Steinbeisser, Carl

AU - Van Gyseghem, Jean-Marc

AU - Niarakis, Anna

AU - Garderet, Laurent

AU - Hudecek, Michael

AU - Neumuth, Thomas

AU - Platzbecker, Uwe

AU - Köhl, Ulrike

AU - Demlova, Regina

AU - Kremer, Andreas

AU - Franke, Stefan

AU - Fröhlich, Holger

AU - Merz, Maximilian

AU - Reiche, Kristin

PY - 2025/8/1

Y1 - 2025/8/1

N2 - In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.

AB - In (immune)oncology, virtual twins (VTs) offer patient-individual decision support. Nevertheless, current VTs do not incorporate the unique properties of engineered adoptive cellular immunotherapies (eACIs). Here, we outline the minimal design specifications for VTs for engineered ACIs (eACI-VTs) to model the complex interplay between cell product and patient physiology. We motivate utilizing VTs in eACIs to provide decision support and reflect on how eACI-VTs can support the widespread use of eACIs.

UR - https://www.scopus.com/pages/publications/105014476463

U2 - 10.1038/s41746-025-01809-6

DO - 10.1038/s41746-025-01809-6

M3 - Article

C2 - 40750653

SN - 2398-6352

VL - 8

JO - npj digital medicine

JF - npj digital medicine

IS - 1

M1 - 493

ER -

Design specifications for biomedical virtual twins in engineered adoptive cellular immunotherapies

Abstract

Access to Document

Other files and links

Fingerprint

Cite this