Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

Anna E. Leeuwis; Astrid M. Hooghiemstra; Raquel Amier; DA Ferro; Leonie Franken; Robin Nijveldt; Joost P A Kuijer; Anne Sophie G T Bronzwaer; Johannes J. van Lieshout; Marc B. Rietberg; Janne M. Veerbeek; Rosalie J. Huijsmans; Frank J G Backx; Charlotte E. Teunissen; Esther E. Bron; Frederik Barkhof; Niels D. Prins; Rahil Shahzad; Wiro J. Niessen; Albert de Roos; Matthias J P van Osch; Albert C. van Rossum; Geert J. Biessels; Wiesje M. van der Flier

doi:10.1016/j.trci.2017.02.002

Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

Anna E. Leeuwis^*, Astrid M. Hooghiemstra, Raquel Amier, DA Ferro, Leonie Franken, Robin Nijveldt, Joost P A Kuijer, Anne Sophie G T Bronzwaer, Johannes J. van Lieshout, Marc B. Rietberg, Janne M. Veerbeek, Rosalie J. Huijsmans, Frank J G Backx, Charlotte E. Teunissen, Esther E. Bron, Frederik Barkhof, Niels D. Prins, Rahil Shahzad, Wiro J. Niessen, Albert de RoosMatthias J P van Osch, Albert C. van Rossum, Geert J. Biessels, Wiesje M. van der Flier

^*Corresponding author for this work

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Abstract

There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.

Original language	English
Pages (from-to)	157-165
Number of pages	9
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.trci.2017.02.002
Publication status	Published - 1 Jun 2017

Keywords

Arterial spin labeling
Cerebral blood flow
Cognition
Exercise
Randomized clinical trial
Vascular cognitive impairment

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10.1016/j.trci.2017.02.002

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Leeuwis, A. E., Hooghiemstra, A. M., Amier, R., Ferro, DA., Franken, L., Nijveldt, R., Kuijer, J. P. A., Bronzwaer, A. S. G. T., van Lieshout, J. J., Rietberg, M. B., Veerbeek, J. M., Huijsmans, R. J., Backx, F. J. G., Teunissen, C. E., Bron, E. E., Barkhof, F., Prins, N. D., Shahzad, R., Niessen, W. J., ... van der Flier, W. M. (2017). Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 3(2), 157-165. https://doi.org/10.1016/j.trci.2017.02.002

@article{48108f2007854517b6e0bcf14199b1af,

title = "Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment",

abstract = "There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.",

keywords = "Arterial spin labeling, Cerebral blood flow, Cognition, Exercise, Randomized clinical trial, Vascular cognitive impairment",

author = "Leeuwis, {Anna E.} and Hooghiemstra, {Astrid M.} and Raquel Amier and DA Ferro and Leonie Franken and Robin Nijveldt and Kuijer, {Joost P A} and Bronzwaer, {Anne Sophie G T} and {van Lieshout}, {Johannes J.} and Rietberg, {Marc B.} and Veerbeek, {Janne M.} and Huijsmans, {Rosalie J.} and Backx, {Frank J G} and Teunissen, {Charlotte E.} and Bron, {Esther E.} and Frederik Barkhof and Prins, {Niels D.} and Rahil Shahzad and Niessen, {Wiro J.} and {de Roos}, Albert and {van Osch}, {Matthias J P} and {van Rossum}, {Albert C.} and Biessels, {Geert J.} and {van der Flier}, {Wiesje M.}",

year = "2017",

month = jun,

day = "1",

doi = "10.1016/j.trci.2017.02.002",

language = "English",

volume = "3",

pages = "157--165",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

publisher = "Wiley",

number = "2",

}

Leeuwis, AE, Hooghiemstra, AM, Amier, R, Ferro, DA, Franken, L, Nijveldt, R, Kuijer, JPA, Bronzwaer, ASGT, van Lieshout, JJ, Rietberg, MB, Veerbeek, JM, Huijsmans, RJ, Backx, FJG, Teunissen, CE, Bron, EE, Barkhof, F, Prins, ND, Shahzad, R, Niessen, WJ, de Roos, A, van Osch, MJP, van Rossum, AC, Biessels, GJ & van der Flier, WM 2017, 'Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment', Alzheimer's and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 2, pp. 157-165. https://doi.org/10.1016/j.trci.2017.02.002

Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment. / Leeuwis, Anna E.; Hooghiemstra, Astrid M.; Amier, Raquel et al.
In: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Vol. 3, No. 2, 01.06.2017, p. 157-165.

Research output: Contribution to journal › Article › Academic › peer-review

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T1 - Design of the ExCersion-VCI study

T2 - The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

AU - Leeuwis, Anna E.

AU - Hooghiemstra, Astrid M.

AU - Amier, Raquel

AU - Ferro, DA

AU - Franken, Leonie

AU - Nijveldt, Robin

AU - Kuijer, Joost P A

AU - Bronzwaer, Anne Sophie G T

AU - van Lieshout, Johannes J.

AU - Rietberg, Marc B.

AU - Veerbeek, Janne M.

AU - Huijsmans, Rosalie J.

AU - Backx, Frank J G

AU - Teunissen, Charlotte E.

AU - Bron, Esther E.

AU - Barkhof, Frederik

AU - Prins, Niels D.

AU - Shahzad, Rahil

AU - Niessen, Wiro J.

AU - de Roos, Albert

AU - van Osch, Matthias J P

AU - van Rossum, Albert C.

AU - Biessels, Geert J.

AU - van der Flier, Wiesje M.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.

AB - There is evidence for a beneficial effect of aerobic exercise on cognition, but underlying mechanisms are unclear. In this study, we test the hypothesis that aerobic exercise increases cerebral blood flow (CBF) in patients with vascular cognitive impairment (VCI). This study is a multicenter single-blind randomized controlled trial among 80 patients with VCI. Most important inclusion criteria are a diagnosis of VCI with Mini-Mental State Examination ≥22 and Clinical Dementia Rating ≤0.5. Participants are randomized into an aerobic exercise group or a control group. The aerobic exercise program aims to improve cardiorespiratory fitness and takes 14 weeks, with a frequency of three times a week. Participants are provided with a bicycle ergometer at home. The control group receives two information meetings. Primary outcome measure is change in CBF. We expect this study to provide insight into the potential mechanism by which aerobic exercise improves hemodynamic status.

KW - Arterial spin labeling

KW - Cerebral blood flow

KW - Cognition

KW - Exercise

KW - Randomized clinical trial

KW - Vascular cognitive impairment

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M3 - Article

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AN - SCOPUS:85016005137

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JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 2

ER -

Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment

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