Design and rationale for Exploring Predictors of successful healthCare Transition for adolescents with chronic conditions in a longitudinal explorative cohort

Background: Transitioning from paediatric to adult healthcare is a pivotal phase for adolescents and young adults
(AYAs) with chronic conditions. Effective healthcare transition (HCT) supports continued healthcare engagement
and stable psychosocial outcomes, reducing risks for patients, their families, and the healthcare system. Yet the
determinants of a smooth transition are complex, shaped by the interplay of various biopsychosocial constructs.
Objective: The ExPeCT study (acronym: Exploring Predictors of a successful healthCare Transition) seeks to: A)
examine the relationship between biopsychosocial development, transition readiness, and HCT outcomes,
including patients’ experiences; and B) identify key predictors of successful HCT in AYAs with chronic
conditions.
Method: This longitudinal, observational, exploratory cohort study is embedded in the PROactive cohort, which
annually measures biopsychosocial well-being of children with chronic conditions. The ExPeCT study supplements
the PROactive cohort by collecting additional data on HCT experiences at three time points: once in
paediatric care and twice after transfer to adult care.
Data will be obtained from a range of chronic disease groups. Advanced statistical modelling will be employed to
analyse transition outcomes and experiences, and to investigate associations between biopsychosocial development
and transition readiness.
Significance: This study is expected to fill a critical gap in the field by providing comprehensive understanding of
predictors of successful healthcare transition in AYAs with chronic conditions. The insights gained will help
improve care strategies and guide healthcare professionals in supporting successful transition to adult care.