Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO2) intoxication

J. Meulenbelt; J. A M A Dormans; L. van Bree; P. J A Rombout; B. Sangster

Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO₂) intoxication

J. Meulenbelt^*, J. A M A Dormans, L. van Bree, P. J A Rombout, B. Sangster

^*Corresponding author for this work

Clinical Toxicology

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

Abstract

In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO₂ intoxication. Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO₂ exposure. Twenty four hours after exposure to 175 ppm NO₂ for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. Desferrioxamine appeared to provide more protection with a dose of 100mg kg^-1 24 h^-1 than with 200 mg kg^-1 24 h^-1.

Original language	English
Pages (from-to)	389-395
Number of pages	7
Journal	Human & Experimental Toxicology
Volume	12
Issue number	5
Publication status	Published - 1 Jan 1993

Cite this

@article{8858170897034177a4c88483d35e493f,

title = "Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO2) intoxication",

abstract = "In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO2 exposure. Twenty four hours after exposure to 175 ppm NO2 for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. Desferrioxamine appeared to provide more protection with a dose of 100mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.",

author = "J. Meulenbelt and Dormans, {J. A M A} and {van Bree}, L. and Rombout, {P. J A} and B. Sangster",

year = "1993",

month = jan,

day = "1",

language = "English",

volume = "12",

pages = "389--395",

number = "5",

}

TY - JOUR

T1 - Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO2) intoxication

AU - Meulenbelt, J.

AU - Dormans, J. A M A

AU - van Bree, L.

AU - Rombout, P. J A

AU - Sangster, B.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO2 exposure. Twenty four hours after exposure to 175 ppm NO2 for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. Desferrioxamine appeared to provide more protection with a dose of 100mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.

AB - In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO2 exposure. Twenty four hours after exposure to 175 ppm NO2 for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. Desferrioxamine appeared to provide more protection with a dose of 100mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.

UR - http://www.scopus.com/inward/record.url?scp=0027290575&partnerID=8YFLogxK

M3 - Article

C2 - 7902116

AN - SCOPUS:0027290575

SN - 0144-5952

VL - 12

SP - 389

EP - 395

JO - Human & Experimental Toxicology

JF - Human & Experimental Toxicology

IS - 5

ER -

Desferrioxamine treatment reduces histological evidence of lung damage in rats after acute nitrogen dioxide (NO₂) intoxication

Abstract

Other files and links

Fingerprint

Cite this