Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis

T R D J Radstake; A W T van Lieshout; P L C M van Riel; W B van den Berg; G J Adema

doi:10.1136/ard.2004.033779

Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis

T R D J Radstake, A W T van Lieshout, P L C M van Riel, W B van den Berg, G J Adema

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Recent findings suggest an important role for Fcgamma receptors and Toll-like receptors expressed by dendritic cells (DC) in the pathogenesis of rheumatoid arthritis (RA). Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA.

Original language	English
Pages (from-to)	1532-8
Number of pages	7
Journal	Annals of the Rheumatic Diseases
Volume	64
Issue number	11
DOIs	https://doi.org/10.1136/ard.2004.033779
Publication status	Published - Nov 2005
Externally published	Yes

Keywords

Arthritis, Rheumatoid
Dendritic Cells
Humans
Immune Tolerance
Receptors, IgG
Synovitis
Toll-Like Receptors
Journal Article
Review

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10.1136/ard.2004.033779

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title = "Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis",

abstract = "Recent findings suggest an important role for Fcgamma receptors and Toll-like receptors expressed by dendritic cells (DC) in the pathogenesis of rheumatoid arthritis (RA). Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA.",

keywords = "Arthritis, Rheumatoid, Dendritic Cells, Humans, Immune Tolerance, Receptors, IgG, Synovitis, Toll-Like Receptors, Journal Article, Review",

author = "Radstake, {T R D J} and {van Lieshout}, {A W T} and {van Riel}, {P L C M} and {van den Berg}, {W B} and Adema, {G J}",

year = "2005",

month = nov,

doi = "10.1136/ard.2004.033779",

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T1 - Dendritic cells, Fc{gamma} receptors, and Toll-like receptors

T2 - potential allies in the battle against rheumatoid arthritis

AU - Radstake, T R D J

AU - van Lieshout, A W T

AU - van Riel, P L C M

AU - van den Berg, W B

AU - Adema, G J

PY - 2005/11

Y1 - 2005/11

N2 - Recent findings suggest an important role for Fcgamma receptors and Toll-like receptors expressed by dendritic cells (DC) in the pathogenesis of rheumatoid arthritis (RA). Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA.

AB - Recent findings suggest an important role for Fcgamma receptors and Toll-like receptors expressed by dendritic cells (DC) in the pathogenesis of rheumatoid arthritis (RA). Possibly, DC behaviour might be tuned to counteract the misbalanced immune system in RA. Understanding the precise mechanisms that determine the skewed immune response in RA may provide new clues for the therapeutic use of DC in RA.

KW - Arthritis, Rheumatoid

KW - Dendritic Cells

KW - Humans

KW - Immune Tolerance

KW - Receptors, IgG

KW - Synovitis

KW - Toll-Like Receptors

KW - Journal Article

KW - Review

U2 - 10.1136/ard.2004.033779

DO - 10.1136/ard.2004.033779

M3 - Article

C2 - 15878905

SN - 0003-4967

VL - 64

SP - 1532

EP - 1538

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 11

ER -

Dendritic cells, Fc{gamma} receptors, and Toll-like receptors: potential allies in the battle against rheumatoid arthritis

Abstract

Keywords

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