Dementia prevention in memory clinics: recommendations from the European task force for brain health services

Giovanni B. Frisoni; Daniele Altomare; Federica Ribaldi; Nicolas Villain; Carol Brayne; Naaheed Mukadam; Marc Abramowicz; Frederik Barkhof; Marcelo Berthier; Melanie Bieler-Aeschlimann; Kaj Blennow; Andrea Brioschi Guevara; Emmanuel Carrera; Gaël Chételat; Chantal Csajka; Jean François Demonet; Alessandra Dodich; Valentina Garibotto; Jean Georges; Samia Hurst; Frank Jessen; Miia Kivipelto; David J. Llewellyn; Laura McWhirter; Richard Milne; Carolina Minguillón; Carlo Miniussi; José Luis Molinuevo; Peter M. Nilsson; Alastair Noyce; Janice M. Ranson; Oriol Grau-Rivera; Jonathan M. Schott; Alina Solomon; Ruth Stephen; Wiesje van der Flier; Cornelia van Duijn; Bruno Vellas; Leonie N.C. Visser; Jeffrey L. Cummings; Philip Scheltens; Craig Ritchie; Bruno Dubois

doi:10.1016/j.lanepe.2022.100576

Dementia prevention in memory clinics: recommendations from the European task force for brain health services

Giovanni B. Frisoni^*, Daniele Altomare, Federica Ribaldi, Nicolas Villain, Carol Brayne, Naaheed Mukadam, Marc Abramowicz, Frederik Barkhof, Marcelo Berthier, Melanie Bieler-Aeschlimann, Kaj Blennow, Andrea Brioschi Guevara, Emmanuel Carrera, Gaël Chételat, Chantal Csajka, Jean François Demonet, Alessandra Dodich, Valentina Garibotto, Jean Georges, Samia HurstFrank Jessen, Miia Kivipelto, David J. Llewellyn, Laura McWhirter, Richard Milne, Carolina Minguillón, Carlo Miniussi, José Luis Molinuevo, Peter M. Nilsson, Alastair Noyce, Janice M. Ranson, Oriol Grau-Rivera, Jonathan M. Schott, Alina Solomon, Ruth Stephen, Wiesje van der Flier, Cornelia van Duijn, Bruno Vellas, Leonie N.C. Visser, Jeffrey L. Cummings, Philip Scheltens, Craig Ritchie, Bruno Dubois

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.

Original language	English
Article number	100576
Journal	The Lancet Regional Health - Europe
Volume	26
DOIs	https://doi.org/10.1016/j.lanepe.2022.100576
Publication status	Published - Mar 2023
Externally published	Yes

Keywords

Cognitive enhancement
Dementia
Memory clinic
Prevention
Risk assessment
Risk communication
Risk reduction

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10.1016/j.lanepe.2022.100576

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Frisoni, G. B., Altomare, D., Ribaldi, F., Villain, N., Brayne, C., Mukadam, N., Abramowicz, M., Barkhof, F., Berthier, M., Bieler-Aeschlimann, M., Blennow, K., Brioschi Guevara, A., Carrera, E., Chételat, G., Csajka, C., Demonet, J. F., Dodich, A., Garibotto, V., Georges, J., ... Dubois, B. (2023). Dementia prevention in memory clinics: recommendations from the European task force for brain health services. The Lancet Regional Health - Europe, 26, Article 100576. https://doi.org/10.1016/j.lanepe.2022.100576

@article{3287ad42d4ae4e6e86968a23b7fe6689,

title = "Dementia prevention in memory clinics: recommendations from the European task force for brain health services",

abstract = "Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.",

keywords = "Cognitive enhancement, Dementia, Memory clinic, Prevention, Risk assessment, Risk communication, Risk reduction",

author = "Frisoni, {Giovanni B.} and Daniele Altomare and Federica Ribaldi and Nicolas Villain and Carol Brayne and Naaheed Mukadam and Marc Abramowicz and Frederik Barkhof and Marcelo Berthier and Melanie Bieler-Aeschlimann and Kaj Blennow and {Brioschi Guevara}, Andrea and Emmanuel Carrera and Ga{\"e}l Ch{\'e}telat and Chantal Csajka and Demonet, {Jean Fran{\c c}ois} and Alessandra Dodich and Valentina Garibotto and Jean Georges and Samia Hurst and Frank Jessen and Miia Kivipelto and Llewellyn, {David J.} and Laura McWhirter and Richard Milne and Carolina Minguill{\'o}n and Carlo Miniussi and Molinuevo, {Jos{\'e} Luis} and Nilsson, {Peter M.} and Alastair Noyce and Ranson, {Janice M.} and Oriol Grau-Rivera and Schott, {Jonathan M.} and Alina Solomon and Ruth Stephen and {van der Flier}, Wiesje and {van Duijn}, Cornelia and Bruno Vellas and Visser, {Leonie N.C.} and Cummings, {Jeffrey L.} and Philip Scheltens and Craig Ritchie and Bruno Dubois",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

month = mar,

doi = "10.1016/j.lanepe.2022.100576",

language = "English",

volume = "26",

journal = "The Lancet Regional Health - Europe",

issn = "2666-7762",

publisher = "Elsevier",

}

Frisoni, GB, Altomare, D, Ribaldi, F, Villain, N, Brayne, C, Mukadam, N, Abramowicz, M, Barkhof, F, Berthier, M, Bieler-Aeschlimann, M, Blennow, K, Brioschi Guevara, A, Carrera, E, Chételat, G, Csajka, C, Demonet, JF, Dodich, A, Garibotto, V, Georges, J, Hurst, S, Jessen, F, Kivipelto, M, Llewellyn, DJ, McWhirter, L, Milne, R, Minguillón, C, Miniussi, C, Molinuevo, JL, Nilsson, PM, Noyce, A, Ranson, JM, Grau-Rivera, O, Schott, JM, Solomon, A, Stephen, R, van der Flier, W, van Duijn, C, Vellas, B, Visser, LNC, Cummings, JL, Scheltens, P, Ritchie, C & Dubois, B 2023, 'Dementia prevention in memory clinics: recommendations from the European task force for brain health services', The Lancet Regional Health - Europe, vol. 26, 100576. https://doi.org/10.1016/j.lanepe.2022.100576

TY - JOUR

T1 - Dementia prevention in memory clinics

T2 - recommendations from the European task force for brain health services

AU - Frisoni, Giovanni B.

AU - Altomare, Daniele

AU - Ribaldi, Federica

AU - Villain, Nicolas

AU - Brayne, Carol

AU - Mukadam, Naaheed

AU - Abramowicz, Marc

AU - Barkhof, Frederik

AU - Berthier, Marcelo

AU - Bieler-Aeschlimann, Melanie

AU - Blennow, Kaj

AU - Brioschi Guevara, Andrea

AU - Carrera, Emmanuel

AU - Chételat, Gaël

AU - Csajka, Chantal

AU - Demonet, Jean François

AU - Dodich, Alessandra

AU - Garibotto, Valentina

AU - Georges, Jean

AU - Hurst, Samia

AU - Jessen, Frank

AU - Kivipelto, Miia

AU - Llewellyn, David J.

AU - McWhirter, Laura

AU - Milne, Richard

AU - Minguillón, Carolina

AU - Miniussi, Carlo

AU - Molinuevo, José Luis

AU - Nilsson, Peter M.

AU - Noyce, Alastair

AU - Ranson, Janice M.

AU - Grau-Rivera, Oriol

AU - Schott, Jonathan M.

AU - Solomon, Alina

AU - Stephen, Ruth

AU - van der Flier, Wiesje

AU - van Duijn, Cornelia

AU - Vellas, Bruno

AU - Visser, Leonie N.C.

AU - Cummings, Jeffrey L.

AU - Scheltens, Philip

AU - Ritchie, Craig

AU - Dubois, Bruno

PY - 2023/3

Y1 - 2023/3

N2 - Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.

AB - Observational population studies indicate that prevention of dementia and cognitive decline is being accomplished, possibly as an unintended result of better vascular prevention and healthier lifestyles. Population aging in the coming decades requires deliberate efforts to further decrease its prevalence and societal burden. Increasing evidence supports the efficacy of preventive interventions on persons with intact cognition and high dementia risk. We report recommendations for the deployment of second-generation memory clinics (Brain Health Services) whose mission is evidence-based and ethical dementia prevention in at-risk individuals. The cornerstone interventions consist of (i) assessment of genetic and potentially modifiable risk factors including brain pathology, and risk stratification, (ii) risk communication with ad-hoc protocols, (iii) risk reduction with multi-domain interventions, and (iv) cognitive enhancement with cognitive and physical training. A roadmap is proposed for concept validation and ensuing clinical deployment.

KW - Cognitive enhancement

KW - Dementia

KW - Memory clinic

KW - Prevention

KW - Risk assessment

KW - Risk communication

KW - Risk reduction

UR - http://www.scopus.com/inward/record.url?scp=85148701592&partnerID=8YFLogxK

U2 - 10.1016/j.lanepe.2022.100576

DO - 10.1016/j.lanepe.2022.100576

M3 - Review article

AN - SCOPUS:85148701592

SN - 2666-7762

VL - 26

JO - The Lancet Regional Health - Europe

JF - The Lancet Regional Health - Europe

M1 - 100576

ER -

Dementia prevention in memory clinics: recommendations from the European task force for brain health services

Abstract

Keywords

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