Delaying the final cut: A close encounter of checkpoint kinases at the midbody

Michael A Hadders; Susanne M A Lens

doi:10.1083/JCB.202012130

Delaying the final cut: A close encounter of checkpoint kinases at the midbody

Michael A Hadders
, Susanne M A Lens

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Abstract

How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2-Cep55, in the midbody center and to delay abscission.

Original language	English
Article number	e202012130
Number of pages	2
Journal	The Journal of cell biology
Volume	220
Issue number	2
DOIs	https://doi.org/10.1083/JCB.202012130
Publication status	Published - 1 Feb 2021

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title = "Delaying the final cut: A close encounter of checkpoint kinases at the midbody",

abstract = "How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2-Cep55, in the midbody center and to delay abscission.",

author = "Hadders, \{Michael A\} and Lens, \{Susanne M A\}",

note = "Funding Information: The Lens laboratory is part of Oncode Institute, which is partly financed by the Dutch Cancer Society. Publisher Copyright: {\textcopyright} 2020 Hadders and Lens.",

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AU - Lens, Susanne M A

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N2 - How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2-Cep55, in the midbody center and to delay abscission.

AB - How chromatin bridges are relayed to the chromosomal passenger complex (CPC) during mammalian cell division is unknown. In this issue, Petsalaki and Zachos (2020. J. Cell Biol.https://doi.org/10.1083/jcb.202008029) show that the DNA damage checkpoint kinases ATM and Chk2 signal to the CPC to associate with a pool of cytoskeletal regulators, MKLP2-Cep55, in the midbody center and to delay abscission.

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DO - 10.1083/JCB.202012130

M3 - Editorial

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JO - The Journal of cell biology

JF - The Journal of cell biology

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Delaying the final cut: A close encounter of checkpoint kinases at the midbody

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