TY - JOUR
T1 - Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Young Patients With a History of Migraine
AU - van Os, Hendrikus J A
AU - Verbaan, Dagmar
AU - Ruigrok, Ynte M
AU - Dennesen, Paul
AU - Müller, Marcella C A
AU - Coert, Bert A
AU - Vergouwen, Mervyn D I
AU - Wermer, Marieke J H
N1 - Publisher Copyright:
© 2022 American Heart Association, Inc.
PY - 2022/6
Y1 - 2022/6
N2 - BACKGROUND: Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort of aSAH patients under 50 years of age.METHODS: In our prospective cohort study, we included patients with aSAH under 50 years of age from 3 hospitals in the Netherlands. We assessed lifetime migraine history with a short screener. Delayed cerebral ischemia was defined as neurological deterioration lasting >1 hour not attributable to other causes by diagnostic workup. Adjustments were made for possible confounders in multivariable Cox regression analyses, and adjusted hazard ratios were calculated.RESULTS: We included 236 young aSAH patients (mean age, 41 years; 64% women) of whom 44 (19%) had a history of migraine (16 with aura). Patients with aSAH and a history of migraine were not at increased risk of developing delayed cerebral ischemia compared with patients without migraine (25% versus 20%; adjusted hazard ratio, 1.16 [95% CI, 0.57-2.35]). Additionally, no increased risk was found in migraine patients with aura (adjusted hazard ratio, 0.85 [95% CI, 0.30-2.44]) or in women (adjusted hazard ratio, 1.24 [95% CI, 0.58-2.68]).CONCLUSIONS: Patients with aSAH under the age of 50 years with a history of migraine are not at increased risk of delayed cerebral ischemia.
AB - BACKGROUND: Young patients with aneurysmal subarachnoid hemorrhage (aSAH) and a history of migraine may have an increased risk of delayed cerebral ischemia. We investigated this potential association in a prospective cohort of aSAH patients under 50 years of age.METHODS: In our prospective cohort study, we included patients with aSAH under 50 years of age from 3 hospitals in the Netherlands. We assessed lifetime migraine history with a short screener. Delayed cerebral ischemia was defined as neurological deterioration lasting >1 hour not attributable to other causes by diagnostic workup. Adjustments were made for possible confounders in multivariable Cox regression analyses, and adjusted hazard ratios were calculated.RESULTS: We included 236 young aSAH patients (mean age, 41 years; 64% women) of whom 44 (19%) had a history of migraine (16 with aura). Patients with aSAH and a history of migraine were not at increased risk of developing delayed cerebral ischemia compared with patients without migraine (25% versus 20%; adjusted hazard ratio, 1.16 [95% CI, 0.57-2.35]). Additionally, no increased risk was found in migraine patients with aura (adjusted hazard ratio, 0.85 [95% CI, 0.30-2.44]) or in women (adjusted hazard ratio, 1.24 [95% CI, 0.58-2.68]).CONCLUSIONS: Patients with aSAH under the age of 50 years with a history of migraine are not at increased risk of delayed cerebral ischemia.
KW - epilepsy
KW - hospitals
KW - middle aged
KW - migraine disorders
KW - subarachnoid hemorrhage
UR - http://www.scopus.com/inward/record.url?scp=85130864036&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.121.038350
DO - 10.1161/STROKEAHA.121.038350
M3 - Article
C2 - 35514282
SN - 0039-2499
VL - 53
SP - 2075
EP - 2077
JO - Stroke
JF - Stroke
IS - 6
ER -