Definitions of Urinary Tract Infection in Current Research: A Systematic Review

Manu P. Bilsen; Rosa M.H. Jongeneel; Caroline Schneeberger; Tamara N. Platteel; Cees Van Nieuwkoop; Lona Mody; Jeffrey M. Caterino; Suzanne E. Geerlings; Bela Köves; Florian Wagenlehner; Simon P. Conroy; Leo G. Visser; Merel M.C. Lambregts

doi:10.1093/ofid/ofad332

Definitions of Urinary Tract Infection in Current Research: A Systematic Review

Manu P. Bilsen^*, Rosa M.H. Jongeneel, Caroline Schneeberger, Tamara N. Platteel, Cees Van Nieuwkoop, Lona Mody, Jeffrey M. Caterino, Suzanne E. Geerlings, Bela Köves, Florian Wagenlehner, Simon P. Conroy, Leo G. Visser, Merel M.C. Lambregts^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

15 Downloads (Pure)

Abstract

Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 10 3 to 10 5 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.

Original language	English
Article number	ofad332
Journal	Open forum infectious diseases
Volume	10
Issue number	7
DOIs	https://doi.org/10.1093/ofid/ofad332
Publication status	Published - 1 Jul 2023

Keywords

complicated urinary tract infection
cystitis
definition
pyelonephritis
urinary tract infection

Access to Document

10.1093/ofid/ofad332Licence: CC BY-NC-ND

ofad332Final published version, 570 KBLicence: CC BY-NC-ND

Cite this

Bilsen, M. P., Jongeneel, R. M. H., Schneeberger, C., Platteel, T. N., Van Nieuwkoop, C., Mody, L., Caterino, J. M., Geerlings, S. E., Köves, B., Wagenlehner, F., Conroy, S. P., Visser, L. G., & Lambregts, M. M. C. (2023). Definitions of Urinary Tract Infection in Current Research: A Systematic Review. Open forum infectious diseases, 10(7), Article ofad332. https://doi.org/10.1093/ofid/ofad332

@article{7d32e50ed9134122bb94bf814d9111e0,

title = "Definitions of Urinary Tract Infection in Current Research: A Systematic Review",

abstract = "Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 10 3 to 10 5 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI. ",

keywords = "complicated urinary tract infection, cystitis, definition, pyelonephritis, urinary tract infection",

author = "Bilsen, {Manu P.} and Jongeneel, {Rosa M.H.} and Caroline Schneeberger and Platteel, {Tamara N.} and {Van Nieuwkoop}, Cees and Lona Mody and Caterino, {Jeffrey M.} and Geerlings, {Suzanne E.} and Bela K{\"o}ves and Florian Wagenlehner and Conroy, {Simon P.} and Visser, {Leo G.} and Lambregts, {Merel M.C.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2023",

month = jul,

day = "1",

doi = "10.1093/ofid/ofad332",

language = "English",

volume = "10",

number = "7",

}

TY - JOUR

T1 - Definitions of Urinary Tract Infection in Current Research

T2 - A Systematic Review

AU - Bilsen, Manu P.

AU - Jongeneel, Rosa M.H.

AU - Schneeberger, Caroline

AU - Platteel, Tamara N.

AU - Van Nieuwkoop, Cees

AU - Mody, Lona

AU - Caterino, Jeffrey M.

AU - Geerlings, Suzanne E.

AU - Köves, Bela

AU - Wagenlehner, Florian

AU - Conroy, Simon P.

AU - Visser, Leo G.

AU - Lambregts, Merel M.C.

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 10 3 to 10 5 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.

AB - Defining urinary tract infection (UTI) is complex, as numerous clinical and diagnostic parameters are involved. In this systematic review, we aimed to gain insight into how UTI is defined across current studies. We included 47 studies, published between January 2019 and May 2022, investigating therapeutic or prophylactic interventions in adult patients with UTI. Signs and symptoms, pyuria, and a positive urine culture were required in 85%, 28%, and 55% of study definitions, respectively. Five studies (11%) required all 3 categories for the diagnosis of UTI. Thresholds for significant bacteriuria varied from 10 3 to 10 5 colony-forming units/mL. None of the 12 studies including acute cystitis and 2 of 12 (17%) defining acute pyelonephritis used identical definitions. Complicated UTI was defined by both host factors and systemic involvement in 9 of 14 (64%) studies. In conclusion, UTI definitions are heterogeneous across recent studies, highlighting the need for a consensus-based, research reference standard for UTI.

KW - complicated urinary tract infection

KW - cystitis

KW - definition

KW - pyelonephritis

KW - urinary tract infection

UR - http://www.scopus.com/inward/record.url?scp=85165405550&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofad332

DO - 10.1093/ofid/ofad332

M3 - Review article

C2 - 37426954

SN - 2328-8957

VL - 10

JO - Open forum infectious diseases

JF - Open forum infectious diseases

IS - 7

M1 - ofad332

ER -

Definitions of Urinary Tract Infection in Current Research: A Systematic Review

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this