Deficiency of the β subunit of the eighth component of complement presenting as arthritis and exanthem

N. M. Wulffraat; E. A M Sanders; C. A P Fijen; A. Hannema; W. Kuis; B. J M Zegers

doi:10.1002/art.1780371121

Deficiency of the β subunit of the eighth component of complement presenting as arthritis and exanthem

N. M. Wulffraat^*, E. A M Sanders, C. A P Fijen, A. Hannema, W. Kuis, B. J M Zegers

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the β subunit of the eighth component of complement. The same deficiency was present in the patient's sister. C8β deficiency is usually detected in individuals who survive meningococcal disease. There was no such history in this family. Juvenile chronic arthritis has not previously been described in patients with C8β deficiency.

Original language	English
Pages (from-to)	1704-1706
Number of pages	3
Journal	Arthritis and Rheumatism
Volume	37
Issue number	11
DOIs	https://doi.org/10.1002/art.1780371121
Publication status	Published - Nov 1994

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title = "Deficiency of the β subunit of the eighth component of complement presenting as arthritis and exanthem",

abstract = "A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the β subunit of the eighth component of complement. The same deficiency was present in the patient's sister. C8β deficiency is usually detected in individuals who survive meningococcal disease. There was no such history in this family. Juvenile chronic arthritis has not previously been described in patients with C8β deficiency.",

author = "Wulffraat, {N. M.} and Sanders, {E. A M} and Fijen, {C. A P} and A. Hannema and W. Kuis and Zegers, {B. J M}",

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AU - Wulffraat, N. M.

AU - Sanders, E. A M

AU - Fijen, C. A P

AU - Hannema, A.

AU - Kuis, W.

AU - Zegers, B. J M

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N2 - A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the β subunit of the eighth component of complement. The same deficiency was present in the patient's sister. C8β deficiency is usually detected in individuals who survive meningococcal disease. There was no such history in this family. Juvenile chronic arthritis has not previously been described in patients with C8β deficiency.

AB - A 13-year-old boy presented with juvenile chronic arthritis of 6 months' duration. Antinuclear antibodies, anti-double-stranded DNA antibodies, and rheumatoid factor were not detected. Western blotting showed a deficiency of the β subunit of the eighth component of complement. The same deficiency was present in the patient's sister. C8β deficiency is usually detected in individuals who survive meningococcal disease. There was no such history in this family. Juvenile chronic arthritis has not previously been described in patients with C8β deficiency.

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JF - Arthritis and Rheumatism

IS - 11

ER -

Deficiency of the β subunit of the eighth component of complement presenting as arthritis and exanthem

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