Decreased lithium clearance due to distal tubular lithium reabsorption in sodium-depleted dogs

W. H. Boer; J. A. Joles; H. A. Koomans; E. J.Dorhout Mees

doi:10.1159/000173115

Decreased lithium clearance due to distal tubular lithium reabsorption in sodium-depleted dogs

W. H. Boer^*, J. A. Joles, H. A. Koomans, E. J.Dorhout Mees

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

24 Citations (Scopus)

Abstract

Lithium clearances were performed in conscious dogs on varying sodium intakes. Fractional lithium excretion (FE-Li) was 22.6±2.2% in sodium-replete dogs (fractional sodium excretion. FE-Na>0.4%, n=l1) but only 6.9±2.3% in sodium-depleted dogs (FE-Na<0.4%, n = 25). In 4 markedly sodium-depleted dogs (FE-Na 0.03±0.02%) the distally acting diuretic amiloride caused an 8-fold increase in FE-Li (from 1.5±1.0 to 11.6 ±2.0%). Our data suggest that tubular reabsorption of lithium in sodium-depleted dogs is not restricted to the proximal tubules but also occurs in the distal nephron. Therefore the lithium clearance cannot be used as an index of sodium and filtrate delivery from the proximal tubules in sodium-depleted dogs.

Original language	English
Pages (from-to)	65-68
Number of pages	4
Journal	Kidney & blood pressure research
Volume	10
Issue number	2
DOIs	https://doi.org/10.1159/000173115
Publication status	Published - 1987

Keywords

Amiloride
Distal tubule
Lithium clearance
Proximal tubule
Sodium intake

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@article{ee04a5b4f87e49f69006062ba0002e98,

title = "Decreased lithium clearance due to distal tubular lithium reabsorption in sodium-depleted dogs",

abstract = "Lithium clearances were performed in conscious dogs on varying sodium intakes. Fractional lithium excretion (FE-Li) was 22.6±2.2\% in sodium-replete dogs (fractional sodium excretion. FE-Na>0.4\%, n=l1) but only 6.9±2.3\% in sodium-depleted dogs (FE-Na<0.4\%, n = 25). In 4 markedly sodium-depleted dogs (FE-Na 0.03±0.02\%) the distally acting diuretic amiloride caused an 8-fold increase in FE-Li (from 1.5±1.0 to 11.6 ±2.0\%). Our data suggest that tubular reabsorption of lithium in sodium-depleted dogs is not restricted to the proximal tubules but also occurs in the distal nephron. Therefore the lithium clearance cannot be used as an index of sodium and filtrate delivery from the proximal tubules in sodium-depleted dogs.",

keywords = "Amiloride, Distal tubule, Lithium clearance, Proximal tubule, Sodium intake",

author = "Boer, \{W. H.\} and Joles, \{J. A.\} and Koomans, \{H. A.\} and Mees, \{E. J.Dorhout\}",

year = "1987",

doi = "10.1159/000173115",

language = "English",

volume = "10",

pages = "65--68",

journal = "Kidney \& blood pressure research",

issn = "1420-4096",

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TY - JOUR

T1 - Decreased lithium clearance due to distal tubular lithium reabsorption in sodium-depleted dogs

AU - Boer, W. H.

AU - Joles, J. A.

AU - Koomans, H. A.

AU - Mees, E. J.Dorhout

PY - 1987

Y1 - 1987

N2 - Lithium clearances were performed in conscious dogs on varying sodium intakes. Fractional lithium excretion (FE-Li) was 22.6±2.2% in sodium-replete dogs (fractional sodium excretion. FE-Na>0.4%, n=l1) but only 6.9±2.3% in sodium-depleted dogs (FE-Na<0.4%, n = 25). In 4 markedly sodium-depleted dogs (FE-Na 0.03±0.02%) the distally acting diuretic amiloride caused an 8-fold increase in FE-Li (from 1.5±1.0 to 11.6 ±2.0%). Our data suggest that tubular reabsorption of lithium in sodium-depleted dogs is not restricted to the proximal tubules but also occurs in the distal nephron. Therefore the lithium clearance cannot be used as an index of sodium and filtrate delivery from the proximal tubules in sodium-depleted dogs.

AB - Lithium clearances were performed in conscious dogs on varying sodium intakes. Fractional lithium excretion (FE-Li) was 22.6±2.2% in sodium-replete dogs (fractional sodium excretion. FE-Na>0.4%, n=l1) but only 6.9±2.3% in sodium-depleted dogs (FE-Na<0.4%, n = 25). In 4 markedly sodium-depleted dogs (FE-Na 0.03±0.02%) the distally acting diuretic amiloride caused an 8-fold increase in FE-Li (from 1.5±1.0 to 11.6 ±2.0%). Our data suggest that tubular reabsorption of lithium in sodium-depleted dogs is not restricted to the proximal tubules but also occurs in the distal nephron. Therefore the lithium clearance cannot be used as an index of sodium and filtrate delivery from the proximal tubules in sodium-depleted dogs.

KW - Amiloride

KW - Distal tubule

KW - Lithium clearance

KW - Proximal tubule

KW - Sodium intake

UR - https://www.scopus.com/pages/publications/84940143458

U2 - 10.1159/000173115

DO - 10.1159/000173115

M3 - Article

C2 - 3447250

AN - SCOPUS:84940143458

SN - 1420-4096

VL - 10

SP - 65

EP - 68

JO - Kidney & blood pressure research

JF - Kidney & blood pressure research

IS - 2

ER -

Decreased lithium clearance due to distal tubular lithium reabsorption in sodium-depleted dogs

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Keywords

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