Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A E Rab; Jennifer Bos; Brigitte van Oirschot; Stephanie van Straaten; Penelope A Kosinski; Victor Chubukov; Hyeryun Kim; Heidi Mangus; Roger E G Schutgens; Gerard Pasterkamp; Lenny Dang; Charles Kung; Eduard J van Beers; Richard van Wijk

doi:10.1182/blood.2020008635

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

Minke A E Rab
, Jennifer Bos
, Brigitte van Oirschot
, Stephanie van Straaten
, Penelope A Kosinski
, Victor Chubukov
, Hyeryun Kim
, Heidi Mangus
, Roger E G Schutgens
, Gerard Pasterkamp
, Lenny Dang
, Charles Kung
, Eduard J van Beers
, Richard van Wijk

Research output: Contribution to journal › Letter › Academic › peer-review

18 Citations (Scopus)

Original language	English
Pages (from-to)	2997-3001
Number of pages	5
Journal	Blood
Volume	137
Issue number	21
Early online date	10 Mar 2021
DOIs	https://doi.org/10.1182/blood.2020008635
Publication status	Published - 27 May 2021

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Rab, M. A. E., Bos, J., van Oirschot, B., Straaten, S. V., Kosinski, P. A., Chubukov, V., Kim, H., Mangus, H., Schutgens, R. E. G., Pasterkamp, G., Dang, L., Kung, C., van Beers, E. J., & van Wijk, R. (2021). Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy. Blood, 137(21), 2997-3001. https://doi.org/10.1182/blood.2020008635

@article{10a011f75d544c9ea198074fef1cddc9,

title = "Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy",

author = "Rab, \{Minke A E\} and Jennifer Bos and \{van Oirschot\}, Brigitte and Straaten, \{Stephanie van\} and Kosinski, \{Penelope A\} and Victor Chubukov and Hyeryun Kim and Heidi Mangus and Schutgens, \{Roger E G\} and Gerard Pasterkamp and Lenny Dang and Charles Kung and \{van Beers\}, \{Eduard J\} and \{van Wijk\}, Richard",

note = "Funding Information: This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).",

year = "2021",

month = may,

day = "27",

doi = "10.1182/blood.2020008635",

language = "English",

volume = "137",

pages = "2997--3001",

journal = "Blood",

issn = "0006-4971",

publisher = "Elsevier",

number = "21",

}

Rab, MAE, Bos, J, van Oirschot, B, Straaten, SV, Kosinski, PA, Chubukov, V, Kim, H, Mangus, H, Schutgens, REG , Pasterkamp, G, Dang, L, Kung, C, van Beers, EJ & van Wijk, R 2021, 'Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy', Blood, vol. 137, no. 21, pp. 2997-3001. https://doi.org/10.1182/blood.2020008635

TY - JOUR

T1 - Decreased activity and stability of pyruvate kinase in sickle cell disease

T2 - a novel target for mitapivat therapy

AU - Rab, Minke A E

AU - Bos, Jennifer

AU - van Oirschot, Brigitte

AU - Straaten, Stephanie van

AU - Kosinski, Penelope A

AU - Chubukov, Victor

AU - Kim, Hyeryun

AU - Mangus, Heidi

AU - Schutgens, Roger E G

AU - Pasterkamp, Gerard

AU - Dang, Lenny

AU - Kung, Charles

AU - van Beers, Eduard J

AU - van Wijk, Richard

N1 - Funding Information: This research has been funded, in part, by Agios Pharmaceuticals Inc and the Eurostars Program (SCOOP, ESTAR18105).

PY - 2021/5/27

Y1 - 2021/5/27

UR - https://www.scopus.com/pages/publications/85106915227

U2 - 10.1182/blood.2020008635

DO - 10.1182/blood.2020008635

M3 - Letter

C2 - 33690814

SN - 0006-4971

VL - 137

SP - 2997

EP - 3001

JO - Blood

JF - Blood

IS - 21

ER -

Decreased activity and stability of pyruvate kinase in sickle cell disease: a novel target for mitapivat therapy

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