Abstract
Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.
| Original language | English |
|---|---|
| Pages (from-to) | 449-62 |
| Number of pages | 14 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2011 |
Keywords
- Animals
- B-Lymphocytes
- Chromosome Aberrations
- Databases, Genetic
- Genetic Predisposition to Disease
- Genetic Testing
- Genome-Wide Association Study
- HLA Antigens
- Humans
- Interferon Regulatory Factors
- Polymorphism, Genetic
- STAT4 Transcription Factor
- Scleroderma, Systemic
- Th17 Cells
- Journal Article
- Review
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