Deciphering the genetic background of systemic sclerosis

Jasper C A Broen; Marieke J H Coenen; Timothy R D J Radstake

doi:10.1586/eci.11.26

Deciphering the genetic background of systemic sclerosis

Jasper C A Broen, Marieke J H Coenen, Timothy R D J Radstake

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.

Original language	English
Pages (from-to)	449-62
Number of pages	14
Journal	Expert Review of Clinical Immunology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1586/eci.11.26
Publication status	Published - Jul 2011

Keywords

Animals
B-Lymphocytes
Chromosome Aberrations
Databases, Genetic
Genetic Predisposition to Disease
Genetic Testing
Genome-Wide Association Study
HLA Antigens
Humans
Interferon Regulatory Factors
Polymorphism, Genetic
STAT4 Transcription Factor
Scleroderma, Systemic
Th17 Cells
Journal Article
Review

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10.1586/eci.11.26

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title = "Deciphering the genetic background of systemic sclerosis",

abstract = "Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.",

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author = "Broen, {Jasper C A} and Coenen, {Marieke J H} and Radstake, {Timothy R D J}",

year = "2011",

month = jul,

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language = "English",

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pages = "449--62",

journal = "Expert Review of Clinical Immunology",

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T1 - Deciphering the genetic background of systemic sclerosis

AU - Broen, Jasper C A

AU - Coenen, Marieke J H

AU - Radstake, Timothy R D J

PY - 2011/7

Y1 - 2011/7

N2 - Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.

AB - Systemic sclerosis (SSc) is a severe autoimmune connective tissue disease. Over the years, evidence for a genetic background of SSc susceptibility has clearly accumulated. This article aims to provide an extensive overview of genetics in SSc research. We discuss indicators for a genetic component present in SSc, family studies, chromosomal aberrances, the involvement of the HLA region and multiple candidate genes and, finally, genome-wide association studies.

KW - Animals

KW - B-Lymphocytes

KW - Chromosome Aberrations

KW - Databases, Genetic

KW - Genetic Predisposition to Disease

KW - Genetic Testing

KW - Genome-Wide Association Study

KW - HLA Antigens

KW - Humans

KW - Interferon Regulatory Factors

KW - Polymorphism, Genetic

KW - STAT4 Transcription Factor

KW - Scleroderma, Systemic

KW - Th17 Cells

KW - Journal Article

KW - Review

U2 - 10.1586/eci.11.26

DO - 10.1586/eci.11.26

M3 - Article

C2 - 21790288

SN - 1744-666X

VL - 7

SP - 449

EP - 462

JO - Expert Review of Clinical Immunology

JF - Expert Review of Clinical Immunology

IS - 4

ER -

Deciphering the genetic background of systemic sclerosis

Abstract

Keywords

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