Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Maarten M Immink; Nicoline A T van der Maas; Mireille N Bekker; Hester E de Melker; Gerco den Hartog; Nynke Y Rots; Pieter G M van Gageldonk; Floris Groenendaal; Elisabeth A M Sanders

doi:10.1093/ofid/ofae717

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Maarten M Immink, Nicoline A T van der Maas^*, Mireille N Bekker, Hester E de Melker, Gerco den Hartog, Nynke Y Rots, Pieter G M van Gageldonk, Floris Groenendaal, Elisabeth A M Sanders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

Original language	English
Article number	ofae717
Journal	Open Forum Infectious Diseases
Volume	12
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofae717
Publication status	Published - Jan 2025

Keywords

antibody decay
full-term
immunogenicity
maternal immunization
pertussis
preterm

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10.1093/ofid/ofae717Licence: CC BY-NC-ND

ofae717Final published version, 545 KBLicence: CC BY-NC-ND

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Immink, M. M., van der Maas, N. A. T., Bekker, M. N., de Melker, H. E., den Hartog, G., Rots, N. Y., van Gageldonk, P. G. M., Groenendaal, F., & Sanders, E. A. M. (2025). Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months. Open Forum Infectious Diseases, 12(1), Article ofae717. https://doi.org/10.1093/ofid/ofae717

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title = "Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months",

abstract = "A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.",

keywords = "antibody decay, full-term, immunogenicity, maternal immunization, pertussis, preterm",

author = "Immink, \{Maarten M\} and \{van der Maas\}, \{Nicoline A T\} and Bekker, \{Mireille N\} and \{de Melker\}, \{Hester E\} and \{den Hartog\}, Gerco and Rots, \{Nynke Y\} and \{van Gageldonk\}, \{Pieter G M\} and Floris Groenendaal and Sanders, \{Elisabeth A M\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2025",

month = jan,

doi = "10.1093/ofid/ofae717",

language = "English",

volume = "12",

number = "1",

}

Immink, MM, van der Maas, NAT, Bekker, MN, de Melker, HE, den Hartog, G, Rots, NY, van Gageldonk, PGM, Groenendaal, F & Sanders, EAM 2025, 'Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months', Open Forum Infectious Diseases, vol. 12, no. 1, ofae717. https://doi.org/10.1093/ofid/ofae717

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months. / Immink, Maarten M; van der Maas, Nicoline A T; Bekker, Mireille N et al.
In: Open Forum Infectious Diseases, Vol. 12, No. 1, ofae717, 01.2025.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

AU - Immink, Maarten M

AU - van der Maas, Nicoline A T

AU - Bekker, Mireille N

AU - de Melker, Hester E

AU - den Hartog, Gerco

AU - Rots, Nynke Y

AU - van Gageldonk, Pieter G M

AU - Groenendaal, Floris

AU - Sanders, Elisabeth A M

N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2025/1

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N2 - A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

AB - A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

KW - antibody decay

KW - full-term

KW - immunogenicity

KW - maternal immunization

KW - pertussis

KW - preterm

UR - https://www.scopus.com/pages/publications/85215834130

U2 - 10.1093/ofid/ofae717

DO - 10.1093/ofid/ofae717

M3 - Article

C2 - 39720465

SN - 2328-8957

VL - 12

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

M1 - ofae717

ER -

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

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