Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Maarten M Immink; Nicoline A T van der Maas; Mireille N Bekker; Hester E de Melker; Gerco den Hartog; Nynke Y Rots; Pieter G M van Gageldonk; Floris Groenendaal; Elisabeth A M Sanders

doi:10.1093/ofid/ofae717

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Maarten M Immink
, Nicoline A T van der Maas^*
, Mireille N Bekker
, Hester E de Melker
, Gerco den Hartog
, Nynke Y Rots
, Pieter G M van Gageldonk
, Floris Groenendaal
, Elisabeth A M Sanders^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

11 Downloads (Pure)

Abstract

A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

Original language	English
Article number	ofae717
Journal	Open Forum Infectious Diseases
Volume	12
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofae717
Publication status	Published - Jan 2025

Keywords

antibody decay
full-term
immunogenicity
maternal immunization
pertussis
preterm

Access to Document

10.1093/ofid/ofae717Licence: CC BY-NC-ND

ofae717Final published version, 545 KBLicence: CC BY-NC-ND

Cite this

Immink, M. M., van der Maas, N. A. T., Bekker, M. N., de Melker, H. E., den Hartog, G., Rots, N. Y., van Gageldonk, P. G. M., Groenendaal, F., & Sanders, E. A. M. (2025). Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months. Open Forum Infectious Diseases, 12(1), Article ofae717. https://doi.org/10.1093/ofid/ofae717

@article{c5b59fbc91dc40818c514d9c3562182e,

title = "Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months",

abstract = "A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.",

keywords = "antibody decay, full-term, immunogenicity, maternal immunization, pertussis, preterm",

author = "Immink, \{Maarten M\} and \{van der Maas\}, \{Nicoline A T\} and Bekker, \{Mireille N\} and \{de Melker\}, \{Hester E\} and \{den Hartog\}, Gerco and Rots, \{Nynke Y\} and \{van Gageldonk\}, \{Pieter G M\} and Floris Groenendaal and Sanders, \{Elisabeth A M\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2025",

month = jan,

doi = "10.1093/ofid/ofae717",

language = "English",

volume = "12",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "1",

}

Immink, MM, van der Maas, NAT, Bekker, MN, de Melker, HE, den Hartog, G, Rots, NY, van Gageldonk, PGM, Groenendaal, F & Sanders, EAM 2025, 'Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months', Open Forum Infectious Diseases, vol. 12, no. 1, ofae717. https://doi.org/10.1093/ofid/ofae717

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months. / Immink, Maarten M; van der Maas, Nicoline A T; Bekker, Mireille N et al.
In: Open Forum Infectious Diseases, Vol. 12, No. 1, ofae717, 01.2025.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

AU - Immink, Maarten M

AU - van der Maas, Nicoline A T

AU - Bekker, Mireille N

AU - de Melker, Hester E

AU - den Hartog, Gerco

AU - Rots, Nynke Y

AU - van Gageldonk, Pieter G M

AU - Groenendaal, Floris

AU - Sanders, Elisabeth A M

N1 - Publisher Copyright: © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

PY - 2025/1

Y1 - 2025/1

N2 - A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

AB - A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

KW - antibody decay

KW - full-term

KW - immunogenicity

KW - maternal immunization

KW - pertussis

KW - preterm

UR - https://www.scopus.com/pages/publications/85215834130

U2 - 10.1093/ofid/ofae717

DO - 10.1093/ofid/ofae717

M3 - Article

C2 - 39720465

SN - 2328-8957

VL - 12

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

M1 - ofae717

ER -

Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this