Decay Rates of Maternal Tetanus, Diphtheria, and Pertussis Antibody Levels in Early and Moderate-to-Late Preterm and Term Infants at Birth and at Two Months

Maarten M Immink, Nicoline A T van der Maas*, Mireille N Bekker, Hester E de Melker, Gerco den Hartog, Nynke Y Rots, Pieter G M van Gageldonk, Floris Groenendaal, Elisabeth A M Sanders*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

A post hoc analysis of maternally derived antibodies at birth and age 2 months following second trimester maternal Tdap vaccination between 20 and 24 weeks' gestational age (GA) showed a faster decay rate of Tdap-related immunoglobulin G in early preterms born before 32 weeks' GA compared with moderate-to-late preterms and full-terms. This is different from previous studies and merits further research.

Original languageEnglish
Article numberofae717
JournalOpen Forum Infectious Diseases
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2025

Keywords

  • antibody decay
  • full-term
  • immunogenicity
  • maternal immunization
  • pertussis
  • preterm

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