Abstract
Atherosclerosis is accompanied by endothelial dysfunction. Nitric oxide, produced by the endothelial cell, has an antiatherogenic and antithrombotic effect. ACE inhibitors have, by limiting the degradation of bradykinin, a beneficial effect on the production of nitric oxide. It has been suggested from the outcomes of the TREND and SAVE studies that ACE inhibitors may have an antithrombotic and antiatherogenic effect. Angiotensin II antagonists possibly lack this beneficial effect of ACE inhibitors.
| Translated title of the contribution | Advantage ACE inhibitors. The effect of RAAS inhibitors on endothelial function |
|---|---|
| Original language | Dutch |
| Pages (from-to) | 906-910 |
| Number of pages | 5 |
| Journal | Pharmaceutisch Weekblad |
| Volume | 135 |
| Issue number | 25 |
| Publication status | Published - 23 Jun 2000 |
Keywords
- Angiotensin II antagonists
- Angiotensin-converting enzyme inhibitors
- Atherosclerosis
- Endothelium
- Nitric oxide