Abstract
RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.
Original language | English |
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Pages (from-to) | 6-7 |
Number of pages | 2 |
Journal | Developmental Cell |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 19 Jan 2010 |
Keywords
- Active Transport, Cell Nucleus/genetics
- Animals
- Cell Nucleus/genetics
- Cytoplasm/genetics
- Heterochromatin/genetics
- Humans
- Intracellular Signaling Peptides and Proteins/genetics
- Nuclear Pore/genetics
- Protein Transport
- RNA Interference/physiology
- Ribonuclease III/genetics
- Schizosaccharomyces/genetics