Dcr1 Tracked Down

L.J.T. Kaaij, R.F. Ketting

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.

Original languageEnglish
Pages (from-to)6-7
Number of pages2
JournalDevelopmental Cell
Volume18
Issue number1
DOIs
Publication statusPublished - 19 Jan 2010

Keywords

  • Active Transport, Cell Nucleus/genetics
  • Animals
  • Cell Nucleus/genetics
  • Cytoplasm/genetics
  • Heterochromatin/genetics
  • Humans
  • Intracellular Signaling Peptides and Proteins/genetics
  • Nuclear Pore/genetics
  • Protein Transport
  • RNA Interference/physiology
  • Ribonuclease III/genetics
  • Schizosaccharomyces/genetics

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