DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba; Sylvie M. Koekkoek; Joost W. Vanhommerig; Kees Brinkman; David Kwa; Jan T.M. Van Der Meer; Maria Prins; Ben Berkhout; Michael Tanck; William A. Paxton; Richard Molenkamp; Janke Schinkel

doi:10.1093/infdis/jix587

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba
, Sylvie M. Koekkoek
, Joost W. Vanhommerig
, Kees Brinkman
, David Kwa
, Jan T.M. Van Der Meer
, Maria Prins
, Ben Berkhout
, Michael Tanck
, William A. Paxton^*
, Richard Molenkamp
, Janke Schinkel

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jix587
Publication status	Published - 1 Feb 2018
Externally published	Yes

Keywords

Adult
Cell Adhesion Molecules/genetics
Genetic Predisposition to Disease
Genotype
Hepatitis C/genetics
Homosexuality, Male
Humans
Lectins, C-Type/genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Prospective Studies
Receptors, Cell Surface/genetics
Substance Abuse, Intravenous/complications
Transcription, Genetic

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10.1093/infdis/jix587

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Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van Der Meer, J. T. M., Prins, M., Berkhout, B., Tanck, M., Paxton, W. A., Molenkamp, R., & Schinkel, J. (2018). DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users. Journal of Infectious Diseases, 217(3), 353-357. https://doi.org/10.1093/infdis/jix587

@article{4f948969840a4c85badebb7af1dd822b,

title = "DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users",

abstract = "We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.",

keywords = "Adult, Cell Adhesion Molecules/genetics, Genetic Predisposition to Disease, Genotype, Hepatitis C/genetics, Homosexuality, Male, Humans, Lectins, C-Type/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Prospective Studies, Receptors, Cell Surface/genetics, Substance Abuse, Intravenous/complications, Transcription, Genetic",

author = "Steba, \{Gaby S.\} and Koekkoek, \{Sylvie M.\} and Vanhommerig, \{Joost W.\} and Kees Brinkman and David Kwa and \{Van Der Meer\}, \{Jan T.M.\} and Maria Prins and Ben Berkhout and Michael Tanck and Paxton, \{William A.\} and Richard Molenkamp and Janke Schinkel",

note = "Funding Information: Financial support. This work was supported by the European Community Seventh Framework Programme (FP7-2007–2013) under grant number HEALTH-F3-2012–305578 and “AIDS Fonds” Netherlands (grant numbers 2008 026 and 2013 037). Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2018",

month = feb,

day = "1",

doi = "10.1093/infdis/jix587",

language = "English",

volume = "217",

pages = "353--357",

journal = "Journal of Infectious Diseases",

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Steba, GS, Koekkoek, SM, Vanhommerig, JW, Brinkman, K, Kwa, D, Van Der Meer, JTM, Prins, M, Berkhout, B, Tanck, M, Paxton, WA, Molenkamp, R & Schinkel, J 2018, 'DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users', Journal of Infectious Diseases, vol. 217, no. 3, pp. 353-357. https://doi.org/10.1093/infdis/jix587

TY - JOUR

T1 - DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

AU - Steba, Gaby S.

AU - Koekkoek, Sylvie M.

AU - Vanhommerig, Joost W.

AU - Brinkman, Kees

AU - Kwa, David

AU - Van Der Meer, Jan T.M.

AU - Prins, Maria

AU - Berkhout, Ben

AU - Tanck, Michael

AU - Paxton, William A.

AU - Molenkamp, Richard

AU - Schinkel, Janke

N1 - Funding Information: Financial support. This work was supported by the European Community Seventh Framework Programme (FP7-2007–2013) under grant number HEALTH-F3-2012–305578 and “AIDS Fonds” Netherlands (grant numbers 2008 026 and 2013 037). Publisher Copyright: © 2017 The Author(s).

PY - 2018/2/1

Y1 - 2018/2/1

N2 - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

AB - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

KW - Adult

KW - Cell Adhesion Molecules/genetics

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Hepatitis C/genetics

KW - Homosexuality, Male

KW - Humans

KW - Lectins, C-Type/genetics

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Prospective Studies

KW - Receptors, Cell Surface/genetics

KW - Substance Abuse, Intravenous/complications

KW - Transcription, Genetic

UR - https://www.scopus.com/pages/publications/85041170330

U2 - 10.1093/infdis/jix587

DO - 10.1093/infdis/jix587

M3 - Review article

C2 - 29140443

AN - SCOPUS:85041170330

SN - 0022-1899

VL - 217

SP - 353

EP - 357

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Abstract

Keywords

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