DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba; Sylvie M. Koekkoek; Joost W. Vanhommerig; Kees Brinkman; David Kwa; Jan T.M. Van Der Meer; Maria Prins; Ben Berkhout; Michael Tanck; William A. Paxton; Richard Molenkamp; Janke Schinkel

doi:10.1093/infdis/jix587

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

Gaby S. Steba, Sylvie M. Koekkoek, Joost W. Vanhommerig, Kees Brinkman, David Kwa, Jan T.M. Van Der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A. Paxton^*, Richard Molenkamp, Janke Schinkel

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

Original language	English
Pages (from-to)	353-357
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	217
Issue number	3
DOIs	https://doi.org/10.1093/infdis/jix587
Publication status	Published - 1 Feb 2018
Externally published	Yes

Keywords

Adult
Cell Adhesion Molecules/genetics
Genetic Predisposition to Disease
Genotype
Hepatitis C/genetics
Homosexuality, Male
Humans
Lectins, C-Type/genetics
Male
Middle Aged
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Prospective Studies
Receptors, Cell Surface/genetics
Substance Abuse, Intravenous/complications
Transcription, Genetic

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10.1093/infdis/jix587

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Steba, G. S., Koekkoek, S. M., Vanhommerig, J. W., Brinkman, K., Kwa, D., Van Der Meer, J. T. M., Prins, M., Berkhout, B., Tanck, M., Paxton, W. A., Molenkamp, R., & Schinkel, J. (2018). DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users. Journal of Infectious Diseases, 217(3), 353-357. https://doi.org/10.1093/infdis/jix587

@article{4f948969840a4c85badebb7af1dd822b,

title = "DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users",

abstract = "We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.",

keywords = "Adult, Cell Adhesion Molecules/genetics, Genetic Predisposition to Disease, Genotype, Hepatitis C/genetics, Homosexuality, Male, Humans, Lectins, C-Type/genetics, Male, Middle Aged, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Prospective Studies, Receptors, Cell Surface/genetics, Substance Abuse, Intravenous/complications, Transcription, Genetic",

author = "Steba, {Gaby S.} and Koekkoek, {Sylvie M.} and Vanhommerig, {Joost W.} and Kees Brinkman and David Kwa and {Van Der Meer}, {Jan T.M.} and Maria Prins and Ben Berkhout and Michael Tanck and Paxton, {William A.} and Richard Molenkamp and Janke Schinkel",

note = "Funding Information: Financial support. This work was supported by the European Community Seventh Framework Programme (FP7-2007–2013) under grant number HEALTH-F3-2012–305578 and “AIDS Fonds” Netherlands (grant numbers 2008 026 and 2013 037). Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2018",

month = feb,

day = "1",

doi = "10.1093/infdis/jix587",

language = "English",

volume = "217",

pages = "353--357",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "3",

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Steba, GS, Koekkoek, SM, Vanhommerig, JW, Brinkman, K, Kwa, D, Van Der Meer, JTM, Prins, M, Berkhout, B, Tanck, M, Paxton, WA, Molenkamp, R & Schinkel, J 2018, 'DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users', Journal of Infectious Diseases, vol. 217, no. 3, pp. 353-357. https://doi.org/10.1093/infdis/jix587

TY - JOUR

T1 - DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

AU - Steba, Gaby S.

AU - Koekkoek, Sylvie M.

AU - Vanhommerig, Joost W.

AU - Brinkman, Kees

AU - Kwa, David

AU - Van Der Meer, Jan T.M.

AU - Prins, Maria

AU - Berkhout, Ben

AU - Tanck, Michael

AU - Paxton, William A.

AU - Molenkamp, Richard

AU - Schinkel, Janke

N1 - Funding Information: Financial support. This work was supported by the European Community Seventh Framework Programme (FP7-2007–2013) under grant number HEALTH-F3-2012–305578 and “AIDS Fonds” Netherlands (grant numbers 2008 026 and 2013 037). Publisher Copyright: © 2017 The Author(s).

PY - 2018/2/1

Y1 - 2018/2/1

N2 - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

AB - We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with hepatitis C virus (HCV) susceptibility. A men who have sex with men (MSM) and an injecting drug users (IDU) cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN single nucleotide polymorphisms (SNPs)-139,-871, and-939 correlated with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors. DC-SIGN promoter SNPs correlated with risk of HCV acquisition via sexual but not IDU exposure, likely through modulation of mRNA expression levels.

KW - Adult

KW - Cell Adhesion Molecules/genetics

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Hepatitis C/genetics

KW - Homosexuality, Male

KW - Humans

KW - Lectins, C-Type/genetics

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Promoter Regions, Genetic

KW - Prospective Studies

KW - Receptors, Cell Surface/genetics

KW - Substance Abuse, Intravenous/complications

KW - Transcription, Genetic

UR - http://www.scopus.com/inward/record.url?scp=85041170330&partnerID=8YFLogxK

U2 - 10.1093/infdis/jix587

DO - 10.1093/infdis/jix587

M3 - Review article

C2 - 29140443

AN - SCOPUS:85041170330

SN - 0022-1899

VL - 217

SP - 353

EP - 357

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 3

ER -

DC-SIGN Polymorphisms Associate with Risk of Hepatitis C Virus Infection among Men who Have Sex with Men but not among Injecting Drug Users

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Keywords

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