Dapsone hypersensitivity syndrome not related to G6PD deficiency

Karlijn J G Schulkes; J W Cohen Tervaert; Feiko Rijken; Lenneke E M Haas

doi:10.1136/bcr-2015-212742

Dapsone hypersensitivity syndrome not related to G6PD deficiency

Karlijn J G Schulkes, J W Cohen Tervaert, Feiko Rijken, Lenneke E M Haas

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.

Original language	English
Journal	BMJ Case Reports [E]
Volume	2015
DOIs	https://doi.org/10.1136/bcr-2015-212742
Publication status	Published - 18 Dec 2015

Keywords

Anti-Infective Agents
Chemical and Drug Induced Liver Injury
Dapsone
Diagnosis, Differential
Drug Hypersensitivity Syndrome
Female
Glucosephosphate Dehydrogenase
Glucosephosphate Dehydrogenase Deficiency
Humans
Middle Aged
Pneumonia
Vasculitis
Case Reports
Journal Article

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10.1136/bcr-2015-212742

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title = "Dapsone hypersensitivity syndrome not related to G6PD deficiency",

abstract = "Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.",

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T1 - Dapsone hypersensitivity syndrome not related to G6PD deficiency

AU - Schulkes, Karlijn J G

AU - Tervaert, J W Cohen

AU - Rijken, Feiko

AU - Haas, Lenneke E M

N1 - 2015 BMJ Publishing Group Ltd.

PY - 2015/12/18

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N2 - Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.

AB - Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. We describe a 55-year-old Caucasian woman with normal glucose-6-phosphate dehydrogenase levels presenting with an extensive skin eruption, high-grade fever, pneumonitis and hepatitis, which occurred within 3 weeks after initiation of dapsone. In addition to supportive care, the patient was successfully treated with high-dose corticosteroids and antibiotics. The combination of high-grade fever, skin rash, lung and liver involvement made a dapsone hypersensitivity syndrome very likely.

KW - Anti-Infective Agents

KW - Chemical and Drug Induced Liver Injury

KW - Dapsone

KW - Diagnosis, Differential

KW - Drug Hypersensitivity Syndrome

KW - Female

KW - Glucosephosphate Dehydrogenase

KW - Glucosephosphate Dehydrogenase Deficiency

KW - Humans

KW - Middle Aged

KW - Pneumonia

KW - Vasculitis

KW - Case Reports

KW - Journal Article

U2 - 10.1136/bcr-2015-212742

DO - 10.1136/bcr-2015-212742

M3 - Article

C2 - 26682839

SN - 1757-790X

VL - 2015

JO - BMJ Case Reports [E]

JF - BMJ Case Reports [E]

ER -

Dapsone hypersensitivity syndrome not related to G6PD deficiency

Abstract

Keywords

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