TY - JOUR
T1 - Daily online contouring and re-planning versus translation-only correction in neurovascular-sparing magnetic resonance-guided radiotherapy for localized prostate cancer
AU - Teunissen, Frederik R
AU - van der Voort van Zyp, Jochem R N
AU - de Groot-van Breugel, Eline N
AU - Verkooijen, Helena M
AU - Wortel, Ruud C
AU - de Boer, Johannes C J
N1 - Funding Information:
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: HV receives research funding from Elekta. The remaining authors declare no potential competing interests.
Funding Information:
This research has been partly funded by ZonMW IMDI/LSH-TKI Foundation (The Hague, The Netherlands, project number 104006004), Elekta AB (Stockholm, Sweden), and Philips Medical Systems (Best, The Netherlands). The funding sources had no involvement in the design of the study, the collection, analysis, and interpretation of the data, nor in the writing and decision to submit the article for publication.
Publisher Copyright:
© 2022 The Author(s)
PY - 2022/10
Y1 - 2022/10
N2 - Neurovascular bundle (NVB) and internal pudendal artery (IPA) sparing during magnetic resonance-guided radiotherapy (MRgRT) for prostate cancer aims for preservation of erectile function. Our present workflow involves daily online contouring and re-planning on a 1.5 T MR-linac, as alternative to conventional (rigid) translation-only corrections of the prostate. We compared planned dose for the NVB and IPA between strategies. Total planned dose was significantly lower with daily online contouring and re-planning for the NVB, but not for the IPA. For the NVB and IPA, the intrapatient difference between highest and lowest fraction dose was significantly smaller for the contouring and re-planning plans.
AB - Neurovascular bundle (NVB) and internal pudendal artery (IPA) sparing during magnetic resonance-guided radiotherapy (MRgRT) for prostate cancer aims for preservation of erectile function. Our present workflow involves daily online contouring and re-planning on a 1.5 T MR-linac, as alternative to conventional (rigid) translation-only corrections of the prostate. We compared planned dose for the NVB and IPA between strategies. Total planned dose was significantly lower with daily online contouring and re-planning for the NVB, but not for the IPA. For the NVB and IPA, the intrapatient difference between highest and lowest fraction dose was significantly smaller for the contouring and re-planning plans.
KW - Adapt-to-position
KW - Adapt-to-shape
KW - Localized prostate cancer
KW - MR-Linac
KW - MRgRT
KW - Neurovascular-sparing
UR - http://www.scopus.com/inward/record.url?scp=85138111040&partnerID=8YFLogxK
U2 - 10.1016/j.phro.2022.09.002
DO - 10.1016/j.phro.2022.09.002
M3 - Article
C2 - 36148156
SN - 2405-6316
VL - 24
SP - 43
EP - 46
JO - Physics and Imaging in Radiation Oncology
JF - Physics and Imaging in Radiation Oncology
ER -