Cytomegalovirus infection induces T-cell differentiation without impairing antigen-specific responses in Gambian infants

David J C Miles, Mariama Sanneh, Beth Holder, Sarah Crozier, Samuel Nyamweya, Ebrima S Touray, Melba S Palmero, Syed M A Zaman, Sarah Rowland-Jones, Marianne van der Sande, Hilton Whittle

Research output: Contribution to journalArticleAcademicpeer-review


Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T-cell differentiation in Gambian infants was associated with impaired specific responses to measles vaccination or polyclonal responses to the superantigen staphylococcal enterotoxin B (SEB). While the concentration of undifferentiated (CD27(+) CD28(+) CCR7(+)) T-cells in peripheral blood was unaffected by CMV, there was a large increase in differentiated (CD28(-) CD57(+)) CD8 T-cells and a smaller increase in differentiated CD4 cells. One week post-vaccination, the CD4 cell interferon-gamma (IFN-gamma) response to measles was lower among CMV-infected infants, but there were no other differences between the cytokine responses, or between the cytokine or proliferative responses 4 months post-vaccination. However, the CD8 T cells of CMV-infected infants proliferated more in response to SEB and the antibody response to measles correlated with the IFN-gamma response to CMV, indicating that CMV infection actually enhances some immune responses in infancy.

Original languageEnglish
Pages (from-to)388-400
Number of pages13
Issue number3
Publication statusPublished - Jul 2008


  • Antibodies, Viral
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Cytomegalovirus Infections
  • Enterotoxins
  • Female
  • Gambia
  • Humans
  • Immunity, Cellular
  • Immunologic Memory
  • Infant
  • Interferon-gamma
  • Male
  • Measles Vaccine
  • Measles virus
  • Superantigens
  • T-Lymphocyte Subsets


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