Abstract
Cytomegalovirus (CMV) infection induces profound differentiation of T cells, and is associated with impaired responses to other immune challenges. We therefore considered whether CMV infection and the consequent T-cell differentiation in Gambian infants was associated with impaired specific responses to measles vaccination or polyclonal responses to the superantigen staphylococcal enterotoxin B (SEB). While the concentration of undifferentiated (CD27(+) CD28(+) CCR7(+)) T-cells in peripheral blood was unaffected by CMV, there was a large increase in differentiated (CD28(-) CD57(+)) CD8 T-cells and a smaller increase in differentiated CD4 cells. One week post-vaccination, the CD4 cell interferon-gamma (IFN-gamma) response to measles was lower among CMV-infected infants, but there were no other differences between the cytokine responses, or between the cytokine or proliferative responses 4 months post-vaccination. However, the CD8 T cells of CMV-infected infants proliferated more in response to SEB and the antibody response to measles correlated with the IFN-gamma response to CMV, indicating that CMV infection actually enhances some immune responses in infancy.
Original language | English |
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Pages (from-to) | 388-400 |
Number of pages | 13 |
Journal | Immunology |
Volume | 124 |
Issue number | 3 |
DOIs | |
Publication status | Published - Jul 2008 |
Keywords
- Antibodies, Viral
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Differentiation
- Cell Proliferation
- Cells, Cultured
- Cytomegalovirus Infections
- Enterotoxins
- Female
- Gambia
- Humans
- Immunity, Cellular
- Immunologic Memory
- Infant
- Interferon-gamma
- Male
- Measles Vaccine
- Measles virus
- Superantigens
- T-Lymphocyte Subsets