Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy

L Vlam; M Stam; W de Jager; E A Cats; L H van den Berg; W L van der Pol

doi:10.1016/j.jneuroim.2015.06.008

Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy

L Vlam, M Stam, W de Jager, E A Cats, L H van den Berg, W L van der Pol

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Journal of Neuroimmunology
Volume	286
DOIs	https://doi.org/10.1016/j.jneuroim.2015.06.008
Publication status	Published - 15 Sept 2015

Keywords

Adult
Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis
Autoantibodies
B-Cell Activating Factor
Chi-Square Distribution
Cytokines
Enzyme-Linked Immunosorbent Assay
Female
G(M1) Ganglioside
Humans
Immunoglobulin M
Male
Middle Aged
Muscular Atrophy, Spinal
Polyneuropathies
Statistics, Nonparametric

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10.1016/j.jneuroim.2015.06.008

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title = "Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy",

abstract = "Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.",

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author = "L Vlam and M Stam and {de Jager}, W and Cats, {E A} and {van den Berg}, {L H} and {van der Pol}, {W L}",

note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",

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AU - Vlam, L

AU - Stam, M

AU - de Jager, W

AU - Cats, E A

AU - van den Berg, L H

AU - van der Pol, W L

PY - 2015/9/15

Y1 - 2015/9/15

N2 - Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.

AB - Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. To further investigate the pathophysiology of MMN and PMA we determined concentrations of 16 mainly B-cell associated inflammatory markers in serum from 25 patients with MMN, 55 patients with PMA, 25 patients with amyotrophic lateral sclerosis (ALS) and 50 healthy controls. Median serum concentrations of the 16 tested cytokines and chemokines were not significantly increased in patients with MMN or patients with PMA, irrespective of the presence of IgM monoclonal gammopathy or high IgM anti-GM1 antibodies. These results argue against a systemic B-cell mediated immune response underlying the pathogenesis of MMN and PMA.

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KW - B-Cell Activating Factor

KW - Chi-Square Distribution

KW - Cytokines

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - G(M1) Ganglioside

KW - Humans

KW - Immunoglobulin M

KW - Male

KW - Middle Aged

KW - Muscular Atrophy, Spinal

KW - Polyneuropathies

KW - Statistics, Nonparametric

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SN - 0165-5728

VL - 286

SP - 1

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy

Abstract

Keywords

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