TY - JOUR
T1 - Cytokine profiles in 1-yr-old very low-birth-weight infants after enteral glutamine supplementation in the neonatal period
AU - Van Zwol, Annelies
AU - Van Den Berg, Anemone
AU - Nieuwenhuis, Edward E.S.
AU - Twisk, Jos W.R.
AU - Fetter, Willem P.F.
AU - Van Elburg, Ruurd M.
PY - 2009/8
Y1 - 2009/8
N2 - In a previous study, we found that glutamine-enriched enteral nutrition in 102 very low-birth-weight (VLBW) infants decreased both the incidence of serious neonatal infections and atopic dermatitis during the first year of life. The aims of this follow-up study were to determine whether these beneficial effects are attended by changes in Th1 and Th2 cytokine profiles at age 1 yr. Furthermore, we studied changes in cytokine profiles during the first year of life in these VLBW infants. In total, 89 infants were eligible for the follow-up study (12 died, 1 exclusion due to a chromosomal abnormality). Th1 (IFN-γ, TNF- α and IL-2) and Th2 cytokine (IL-10, IL-5, and IL-4) profiles following in vitro whole blood stimulation were measured at 1 yr. Cytokine profiles were measured in 59/89 (66%) infants. Glutamine-enriched enteral nutrition in neonatal period did not influence cytokine profiles at 1 yr. Cytokine profiles were not different in infants with and without allergic or infectious diseases. The beneficial effect of glutamine-enriched enteral nutrition on the incidence of serious neonatal infections and atopic dermatitis during the first year of life is not related to changes in the Th1 and Th2 cytokine profiles. Both Th1 and Th2 cytokine profiles increased during the first year of life in this cohort of VLBW infants.
AB - In a previous study, we found that glutamine-enriched enteral nutrition in 102 very low-birth-weight (VLBW) infants decreased both the incidence of serious neonatal infections and atopic dermatitis during the first year of life. The aims of this follow-up study were to determine whether these beneficial effects are attended by changes in Th1 and Th2 cytokine profiles at age 1 yr. Furthermore, we studied changes in cytokine profiles during the first year of life in these VLBW infants. In total, 89 infants were eligible for the follow-up study (12 died, 1 exclusion due to a chromosomal abnormality). Th1 (IFN-γ, TNF- α and IL-2) and Th2 cytokine (IL-10, IL-5, and IL-4) profiles following in vitro whole blood stimulation were measured at 1 yr. Cytokine profiles were measured in 59/89 (66%) infants. Glutamine-enriched enteral nutrition in neonatal period did not influence cytokine profiles at 1 yr. Cytokine profiles were not different in infants with and without allergic or infectious diseases. The beneficial effect of glutamine-enriched enteral nutrition on the incidence of serious neonatal infections and atopic dermatitis during the first year of life is not related to changes in the Th1 and Th2 cytokine profiles. Both Th1 and Th2 cytokine profiles increased during the first year of life in this cohort of VLBW infants.
KW - Follow-up study
KW - Glutamine
KW - Infant
KW - Th /Th cytokines
KW - Very low-birth-weight
UR - http://www.scopus.com/inward/record.url?scp=68349117326&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3038.2008.00813.x
DO - 10.1111/j.1399-3038.2008.00813.x
M3 - Article
C2 - 19175893
AN - SCOPUS:68349117326
SN - 0905-6157
VL - 20
SP - 467
EP - 470
JO - Pediatric Allergy and Immunology
JF - Pediatric Allergy and Immunology
IS - 5
ER -