CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people

Maren I Blonk; Nathalie van der Velde; Patricia M L A van den Bemt; Ron H N van Schaik; Tischa J M van der Cammen

doi:10.1007/s11096-009-9349-1

CYP2D64, CYP3A53 and ABCB1 3435T polymorphisms and drug-related falls in elderly people

Maren I Blonk
, Nathalie van der Velde
, Patricia M L A van den Bemt
, Ron H N van Schaik
, Tischa J M van der Cammen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: The objective of this study is to investigate the association between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls.

METHOD: Multivariate logistic regression was performed in an existing database in order to study the association between falls history and CYP2D6*4, CYP3A5*3, ABCB1 3435T polymorphisms in patients using fall-risk-increasing CYP2D6, CYP3A5 and P-glycoprotein (gene product of ABCB1) substrates.

RESULTS: No statistically significant increased fall risk was found in 'poor metabolizers' compared to 'extensive' and 'intermediate metabolizers' using fall-risk-increasing CYP2D6 substrates (Odds ratio (OR) = 2.2; 95% confidence interval (CI) 0.2-25.0), CYP3A5 substrates (OR = 0.9; 95% CI 0.2-3.3) and P-glycoprotein substrates (OR = 2.1; 95% CI 0.2-17.2).

CONCLUSION: The hypothesis that 'poor metabolizers' have an increased fall risk was not confirmed. A larger study population is needed to confirm the potential association that was seen between CYP2D6*4 and ABCB1 3435T polymorphisms and drug-related falls.

Original language	English
Pages (from-to)	26-9
Number of pages	4
Journal	Pharmacy World & Science
Volume	32
Issue number	1
DOIs	https://doi.org/10.1007/s11096-009-9349-1
Publication status	Published - Feb 2010
Externally published	Yes

Keywords

ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics
Accidental Falls/statistics & numerical data
Aged
Aged, 80 and over
Cytochrome P-450 CYP2D6/genetics
Cytochrome P-450 CYP3A/genetics
Female
Genetic Association Studies
Humans
Male
Pharmacokinetics
Polymorphism, Genetic
Retrospective Studies
Risk Factors
Statistics as Topic

Access to Document

10.1007/s11096-009-9349-1

Cite this

@article{66b651ef33b7431db7ffc6ca319a9d84,

title = "CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people",

abstract = "OBJECTIVE: The objective of this study is to investigate the association between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls.METHOD: Multivariate logistic regression was performed in an existing database in order to study the association between falls history and CYP2D6*4, CYP3A5*3, ABCB1 3435T polymorphisms in patients using fall-risk-increasing CYP2D6, CYP3A5 and P-glycoprotein (gene product of ABCB1) substrates.RESULTS: No statistically significant increased fall risk was found in 'poor metabolizers' compared to 'extensive' and 'intermediate metabolizers' using fall-risk-increasing CYP2D6 substrates (Odds ratio (OR) = 2.2; 95\% confidence interval (CI) 0.2-25.0), CYP3A5 substrates (OR = 0.9; 95\% CI 0.2-3.3) and P-glycoprotein substrates (OR = 2.1; 95\% CI 0.2-17.2).CONCLUSION: The hypothesis that 'poor metabolizers' have an increased fall risk was not confirmed. A larger study population is needed to confirm the potential association that was seen between CYP2D6*4 and ABCB1 3435T polymorphisms and drug-related falls.",

keywords = "ATP Binding Cassette Transporter, Subfamily B, ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics, Accidental Falls/statistics \& numerical data, Aged, Aged, 80 and over, Cytochrome P-450 CYP2D6/genetics, Cytochrome P-450 CYP3A/genetics, Female, Genetic Association Studies, Humans, Male, Pharmacokinetics, Polymorphism, Genetic, Retrospective Studies, Risk Factors, Statistics as Topic",

author = "Blonk, \{Maren I\} and \{van der Velde\}, Nathalie and \{van den Bemt\}, \{Patricia M L A\} and \{van Schaik\}, \{Ron H N\} and \{van der Cammen\}, \{Tischa J M\}",

year = "2010",

month = feb,

doi = "10.1007/s11096-009-9349-1",

language = "English",

volume = "32",

pages = "26--9",

journal = "Pharmacy World \& Science",

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publisher = "Kluwer Academic Publishers",

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T1 - CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls in elderly people

AU - Blonk, Maren I

AU - van der Velde, Nathalie

AU - van den Bemt, Patricia M L A

AU - van Schaik, Ron H N

AU - van der Cammen, Tischa J M

PY - 2010/2

Y1 - 2010/2

N2 - OBJECTIVE: The objective of this study is to investigate the association between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls.METHOD: Multivariate logistic regression was performed in an existing database in order to study the association between falls history and CYP2D6*4, CYP3A5*3, ABCB1 3435T polymorphisms in patients using fall-risk-increasing CYP2D6, CYP3A5 and P-glycoprotein (gene product of ABCB1) substrates.RESULTS: No statistically significant increased fall risk was found in 'poor metabolizers' compared to 'extensive' and 'intermediate metabolizers' using fall-risk-increasing CYP2D6 substrates (Odds ratio (OR) = 2.2; 95% confidence interval (CI) 0.2-25.0), CYP3A5 substrates (OR = 0.9; 95% CI 0.2-3.3) and P-glycoprotein substrates (OR = 2.1; 95% CI 0.2-17.2).CONCLUSION: The hypothesis that 'poor metabolizers' have an increased fall risk was not confirmed. A larger study population is needed to confirm the potential association that was seen between CYP2D6*4 and ABCB1 3435T polymorphisms and drug-related falls.

AB - OBJECTIVE: The objective of this study is to investigate the association between CYP2D6*4, CYP3A5*3 and ABCB1 3435T polymorphisms and drug-related falls.METHOD: Multivariate logistic regression was performed in an existing database in order to study the association between falls history and CYP2D6*4, CYP3A5*3, ABCB1 3435T polymorphisms in patients using fall-risk-increasing CYP2D6, CYP3A5 and P-glycoprotein (gene product of ABCB1) substrates.RESULTS: No statistically significant increased fall risk was found in 'poor metabolizers' compared to 'extensive' and 'intermediate metabolizers' using fall-risk-increasing CYP2D6 substrates (Odds ratio (OR) = 2.2; 95% confidence interval (CI) 0.2-25.0), CYP3A5 substrates (OR = 0.9; 95% CI 0.2-3.3) and P-glycoprotein substrates (OR = 2.1; 95% CI 0.2-17.2).CONCLUSION: The hypothesis that 'poor metabolizers' have an increased fall risk was not confirmed. A larger study population is needed to confirm the potential association that was seen between CYP2D6*4 and ABCB1 3435T polymorphisms and drug-related falls.

KW - ATP Binding Cassette Transporter, Subfamily B

KW - ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics

KW - Accidental Falls/statistics & numerical data

KW - Aged

KW - Aged, 80 and over

KW - Cytochrome P-450 CYP2D6/genetics

KW - Cytochrome P-450 CYP3A/genetics

KW - Female

KW - Genetic Association Studies

KW - Humans

KW - Male

KW - Pharmacokinetics

KW - Polymorphism, Genetic

KW - Retrospective Studies

KW - Risk Factors

KW - Statistics as Topic

U2 - 10.1007/s11096-009-9349-1

DO - 10.1007/s11096-009-9349-1

M3 - Article

C2 - 19946748

SN - 0928-1231

VL - 32

SP - 26

EP - 29

JO - Pharmacy World & Science

JF - Pharmacy World & Science

IS - 1

ER -