Cyclosporin A inhibits IL 2-driven proliferation of human alloactivated T cells

W. A. Buurman; T. J.M. Ruers; I. A.J.J.M. Daemen; C. J. van der Linden; G. Groenewegen

Cyclosporin A inhibits IL 2-driven proliferation of human alloactivated T cells

W. A. Buurman, T. J.M. Ruers, I. A.J.J.M. Daemen, C. J. van der Linden, G. Groenewegen

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Abstract

The influence of cyclosporin A (CsA) on the interleukin 2 (IL 2)-driven proliferation of allo-activated human T lymphocytes has been studied. CsA (50, 100, and 250 ng/ml) appeared to affect the IL 2-driven proliferation. The impaired proliferation could not be reversed with exogenous interferon-γ. The doubling time of the cell populations appeared to increase with higher CsA doses. The cytotoxic capacity of the cells was also strongly inhibited by CsA. The cells regained proliferative and cytotoxic properties after CsA has been removed and cells were additionally cultured in normal medium. The data strongly suggest that CsA has an inhibitory influence on essential basic processes in T cells.

Original language	English
Pages (from-to)	4035-4039
Number of pages	5
Journal	Journal of Immunology
Volume	136
Issue number	11
Publication status	Published - 6 Aug 1986

Cite this

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title = "Cyclosporin A inhibits IL 2-driven proliferation of human alloactivated T cells",

abstract = "The influence of cyclosporin A (CsA) on the interleukin 2 (IL 2)-driven proliferation of allo-activated human T lymphocytes has been studied. CsA (50, 100, and 250 ng/ml) appeared to affect the IL 2-driven proliferation. The impaired proliferation could not be reversed with exogenous interferon-γ. The doubling time of the cell populations appeared to increase with higher CsA doses. The cytotoxic capacity of the cells was also strongly inhibited by CsA. The cells regained proliferative and cytotoxic properties after CsA has been removed and cells were additionally cultured in normal medium. The data strongly suggest that CsA has an inhibitory influence on essential basic processes in T cells.",

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AU - Buurman, W. A.

AU - Ruers, T. J.M.

AU - Daemen, I. A.J.J.M.

AU - van der Linden, C. J.

AU - Groenewegen, G.

PY - 1986/8/6

Y1 - 1986/8/6

N2 - The influence of cyclosporin A (CsA) on the interleukin 2 (IL 2)-driven proliferation of allo-activated human T lymphocytes has been studied. CsA (50, 100, and 250 ng/ml) appeared to affect the IL 2-driven proliferation. The impaired proliferation could not be reversed with exogenous interferon-γ. The doubling time of the cell populations appeared to increase with higher CsA doses. The cytotoxic capacity of the cells was also strongly inhibited by CsA. The cells regained proliferative and cytotoxic properties after CsA has been removed and cells were additionally cultured in normal medium. The data strongly suggest that CsA has an inhibitory influence on essential basic processes in T cells.

AB - The influence of cyclosporin A (CsA) on the interleukin 2 (IL 2)-driven proliferation of allo-activated human T lymphocytes has been studied. CsA (50, 100, and 250 ng/ml) appeared to affect the IL 2-driven proliferation. The impaired proliferation could not be reversed with exogenous interferon-γ. The doubling time of the cell populations appeared to increase with higher CsA doses. The cytotoxic capacity of the cells was also strongly inhibited by CsA. The cells regained proliferative and cytotoxic properties after CsA has been removed and cells were additionally cultured in normal medium. The data strongly suggest that CsA has an inhibitory influence on essential basic processes in T cells.

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VL - 136

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EP - 4039

JO - Journal of Immunology

JF - Journal of Immunology

IS - 11

ER -

Cyclosporin A inhibits IL 2-driven proliferation of human alloactivated T cells

Abstract

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